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Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity Export

Nature Neuroscience, Vol. 12, No. 2. (25 January 2009), pp. 190-199.

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090228 jc jeongyeon

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Individual prefrontal cortex neurons can exhibit persistent activity during a delay between a cue and a behavioral response. Here the authors report on an mGluR5-mediated depolarization that underlies persistent activity and is sensitive to both dopamine and cocaine.


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