Sleep transforms the cerebral trace of declarative memories Export

@article{citeulike:1934397, abstract = {After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level. 10.1073/pnas.0705454104}, author = {Gais, Steffen and Albouy, Genevieve and Boly, Melanie and Dang-Vu, Thien T. and Darsaud, Annabelle and Desseilles, Martin and Rauchs, Geraldine and Schabus, Manuel and Sterpenich, Virginie and Vandewalle, Gilles and Maquet, Pierre and Peigneux, Philippe}, citeulike-article-id = {1934397}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0705454104}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18000060}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18000060}, doi = {10.1073/pnas.0705454104}, journal = {Proceedings of the National Academy of Sciences}, month = {November}, pages = {0705454104+}, posted-at = {2007-11-18 21:18:33}, priority = {2}, title = {Sleep transforms the cerebral trace of declarative memories}, url = {http://dx.doi.org/10.1073/pnas.0705454104}, year = {2007} }

TY - JOUR ID - citeulike:1934397 L3 - citeulike-article-id:1934397 N2 - After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level. 10.1073/pnas.0705454104 JF - Proceedings of the National Academy of Sciences TI - Sleep transforms the cerebral trace of declarative memories SP - 0705454104 AU - Gais, Steffen AU - Albouy, Genevieve AU - Boly, Melanie AU - Dang-Vu, Thien AU - Darsaud, Annabelle AU - Desseilles, Martin AU - Rauchs, Geraldine AU - Schabus, Manuel AU - Sterpenich, Virginie AU - Vandewalle, Gilles AU - Maquet, Pierre AU - Peigneux, Philippe PY - 2007/11/13/ UR - http://dx.doi.org/10.1073/pnas.0705454104 ER -