Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

by: N Jenkinson, D Nandi, RC Miall, JF Stein, TZ Aziz

Neuroreport, Vol. 15, No. 17. (3 December 2004), pp. 2621-2624.

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Abstract

We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activity while low frequency stimulation increases it significantly over baseline. After making the monkey Parkinsonian with MPTP, unilateral low frequency stimulation of the pedunculopontine nuclei led to significant increases in activity. These results suggest that pedunculopontine nuclei stimulation could be clinically effective in treating advanced Parkinson's disease and other akinetic disorders.

@article{citeulike:1533441, abstract = {We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activity while low frequency stimulation increases it significantly over baseline. After making the monkey Parkinsonian with MPTP, unilateral low frequency stimulation of the pedunculopontine nuclei led to significant increases in activity. These results suggest that pedunculopontine nuclei stimulation could be clinically effective in treating advanced Parkinson's disease and other akinetic disorders.}, address = {University Laboratory of Physiology, Oxford University, Parks Road, Oxford, UK.}, author = {Jenkinson, N. and Nandi, D. and Miall, R. C. and Stein, J. F. and Aziz, T. Z. }, citeulike-article-id = {1533441}, issn = {0959-4965}, journal = {Neuroreport}, keywords = {dbs, ppn}, month = {December}, number = {17}, pages = {2621--2624}, posted-at = {2007-08-03 15:18:47}, priority = {2}, title = {Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15570164}, volume = {15}, year = {2004} }

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TY - JOUR ID - citeulike:1533441 L3 - citeulike-article-id:1533441 TI - Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey. JF - Neuroreport VL - 15 IS - 17 SP - 2621 EP - 2624 AD - University Laboratory of Physiology, Oxford University, Parks Road, Oxford, UK. SN - 0959-4965 N2 - We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activity while low frequency stimulation increases it significantly over baseline. After making the monkey Parkinsonian with MPTP, unilateral low frequency stimulation of the pedunculopontine nuclei led to significant increases in activity. These results suggest that pedunculopontine nuclei stimulation could be clinically effective in treating advanced Parkinson's disease and other akinetic disorders. KW - dbs KW - ppn AU - Jenkinson, N AU - Nandi, D AU - Miall, RC AU - Stein, JF AU - Aziz, TZ PY - 2004/12/03/ UR - http://view.ncbi.nlm.nih.gov/pubmed/15570164 ER -

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