Prevolutionary dynamics and the origin of evolution Export

@article{citeulike:3269030, abstract = {10.1073/pnas.0806714105 Life is that which replicates and evolves. The origin of life is also the origin of evolution. A fundamental question is when do chemical kinetics become evolutionary dynamics? Here, we formulate a general mathematical theory for the origin of evolution. All known life on earth is based on biological polymers, which act as information carriers and catalysts. Therefore, any theory for the origin of life must address the emergence of such a system. We describe prelife as an alphabet of active monomers that form random polymers. Prelife is a generative system that can produce information. Prevolutionary dynamics have selection and mutation, but no replication. Life marches in with the ability of replication: Polymers act as templates for their own reproduction. Prelife is a scaffold that builds life. Yet, there is competition between life and prelife. There is a phase transition: If the effective replication rate exceeds a critical value, then life outcompetes prelife. Replication is not a prerequisite for selection, but instead, there can be selection for replication. Mutation leads to an error threshold between life and prelife.}, author = {Nowak, Martin A. and Ohtsuki, Hisashi}, citeulike-article-id = {3269030}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0806714105}, citeulike-linkout-1 = {http://www.pnas.org/content/0806714105v1//.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/0806714105v1//.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18791073}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18791073}, day = {30}, doi = {10.1073/pnas.0806714105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biology, chemistry, dynamics, evolution, mutation, replication, selection}, month = {September}, number = {39}, pages = {14924--14927}, posted-at = {2009-11-02 20:47:30}, priority = {2}, title = {Prevolutionary dynamics and the origin of evolution}, url = {http://dx.doi.org/10.1073/pnas.0806714105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3269030 L3 - citeulike-article-id:3269030 N2 - 10.1073/pnas.0806714105 Life is that which replicates and evolves. The origin of life is also the origin of evolution. A fundamental question is when do chemical kinetics become evolutionary dynamics? Here, we formulate a general mathematical theory for the origin of evolution. All known life on earth is based on biological polymers, which act as information carriers and catalysts. Therefore, any theory for the origin of life must address the emergence of such a system. We describe prelife as an alphabet of active monomers that form random polymers. Prelife is a generative system that can produce information. Prevolutionary dynamics have selection and mutation, but no replication. Life marches in with the ability of replication: Polymers act as templates for their own reproduction. Prelife is a scaffold that builds life. Yet, there is competition between life and prelife. There is a phase transition: If the effective replication rate exceeds a critical value, then life outcompetes prelife. Replication is not a prerequisite for selection, but instead, there can be selection for replication. Mutation leads to an error threshold between life and prelife. IS - 39 JF - Proceedings of the National Academy of Sciences EP - 14927 TI - Prevolutionary dynamics and the origin of evolution VL - 105 SP - 14924 KW - biology KW - chemistry KW - dynamics KW - evolution KW - mutation KW - replication KW - selection AU - Nowak, Martin AU - Ohtsuki, Hisashi PY - 2008/09/30/ UR - http://dx.doi.org/10.1073/pnas.0806714105 ER -