Systematic Mapping of Genetic Interaction Networks Export

@article{citeulike:6081691, abstract = {Genetic interactions influencing a phenotype of interest can be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast Saccharomyces cerevisiae have identified thousands of genetic interactions and provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria Escherichia coli and the yeast Schizosaccharomyces pombe, opening the way to comparative investigations of interaction networks. Genetic interaction screens in Caenorhabditis elegans, Drosophila melanogaster, and mammalian models are helping to improve our understanding of metazoan-specific signaling pathways. Together, our emerging knowledge of the genetic wiring diagrams of eukaryotic and prokaryotic cells is providing a new understanding of the relationship between genotype and phenotype.}, author = {Dixon, Scott J. and Costanzo, Michael and Baryshnikova, Anastasia and Andrews, Brenda and Boone, Charles}, citeulike-article-id = {6081691}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.genet.39.073003.114751}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.genet.39.073003.114751}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19712041}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19712041}, day = {27}, doi = {10.1146/annurev.genet.39.073003.114751}, issn = {1545-2948}, journal = {Annual Review of Genetics}, keywords = {boone, genetic, interaction, yeast}, month = {August}, number = {1}, pages = {601--625}, posted-at = {2009-11-07 00:56:13}, priority = {2}, title = {Systematic Mapping of Genetic Interaction Networks}, url = {http://dx.doi.org/10.1146/annurev.genet.39.073003.114751}, volume = {43}, year = {2009} }

TY - JOUR ID - citeulike:6081691 L3 - citeulike-article-id:6081691 N2 - Genetic interactions influencing a phenotype of interest can be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast Saccharomyces cerevisiae have identified thousands of genetic interactions and provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria Escherichia coli and the yeast Schizosaccharomyces pombe, opening the way to comparative investigations of interaction networks. Genetic interaction screens in Caenorhabditis elegans, Drosophila melanogaster, and mammalian models are helping to improve our understanding of metazoan-specific signaling pathways. Together, our emerging knowledge of the genetic wiring diagrams of eukaryotic and prokaryotic cells is providing a new understanding of the relationship between genotype and phenotype. IS - 1 JF - Annual Review of Genetics SN - 1545-2948 EP - 625 TI - Systematic Mapping of Genetic Interaction Networks VL - 43 SP - 601 KW - boone KW - genetic KW - interaction KW - yeast AU - Dixon, Scott AU - Costanzo, Michael AU - Baryshnikova, Anastasia AU - Andrews, Brenda AU - Boone, Charles PY - 2009/08/27/ UR - http://dx.doi.org/10.1146/annurev.genet.39.073003.114751 ER -