Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

@article{citeulike:105085, abstract = {In the mammalian auditory system, sensory cell loss resulting from aging, ototoxic drugs, infections, overstimulation and other causes is irreversible and leads to permanent sensorineural hearing loss. To restore hearing, it is necessary to generate new functional hair cells. One potential way to regenerate hair cells is to induce a phenotypic transdifferentiation of nonsensory cells that remain in the deaf cochlea. Here we report that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and key regulator of hair cell development, induces regeneration of hair cells and substantially improves hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors. This is the first demonstration of cellular and functional repair in the organ of Corti of a mature deaf mammal. The data suggest a new therapeutic approach based on expressing crucial developmental genes for cellular and functional restoration in the damaged auditory epithelium and other sensory systems. http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/vaop/ncurrent/full/nm1193.html}, author = {Izumikawa, Masahiko and Minoda, Ryosei and Kawamoto, Kohei and Abrashkin, Karen A. and Swiderski, Donald L. and Dolan, David F. and Brough, Douglas E. and Raphael, Yehoash }, citeulike-article-id = {105085}, journal = {Nature Medicine}, keywords = {audition, gene\_therapy, hearing, regeneration}, month = {February}, posted-at = {2005-02-26 20:43:36}, priority = {2}, title = {Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals}, url = {http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/vaop/ncurrent/full/nm1193.html}, year = {2005} }

TY - JOUR ID - citeulike:105085 L3 - citeulike-article-id:105085 TI - Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals JF - Nature Medicine N2 - In the mammalian auditory system, sensory cell loss resulting from aging, ototoxic drugs, infections, overstimulation and other causes is irreversible and leads to permanent sensorineural hearing loss. To restore hearing, it is necessary to generate new functional hair cells. One potential way to regenerate hair cells is to induce a phenotypic transdifferentiation of nonsensory cells that remain in the deaf cochlea. Here we report that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and key regulator of hair cell development, induces regeneration of hair cells and substantially improves hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors. This is the first demonstration of cellular and functional repair in the organ of Corti of a mature deaf mammal. The data suggest a new therapeutic approach based on expressing crucial developmental genes for cellular and functional restoration in the damaged auditory epithelium and other sensory systems. http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/vaop/ncurrent/full/nm1193.html KW - audition KW - gene_therapy KW - hearing KW - regeneration AU - Izumikawa, Masahiko AU - Minoda, Ryosei AU - Kawamoto, Kohei AU - Abrashkin, Karen AU - Swiderski, Donald AU - Dolan, David AU - Brough, Douglas AU - Raphael, Yehoash PY - 2005/02// UR - http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/vaop/ncurrent/full/nm1193.html ER -