Dissociable Neural Responses in Human Reward Systems

@article{citeulike:1325557, abstract = {Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.}, author = {Elliott, Rebecca and Friston, Karl J. and Dolan, Raymond J. }, citeulike-article-id = {1325557}, journal = {J. Neurosci.}, keywords = {fmri, globus\_pallidus, hippocampus, penalties, rewards, striatum}, month = {August}, number = {16}, pages = {6159--6165}, posted-at = {2007-05-24 18:50:05}, priority = {2}, title = {Dissociable Neural Responses in Human Reward Systems}, url = {http://www.jneurosci.org/cgi/content/abstract/20/16/6159}, volume = {20}, year = {2000} }

TY - JOUR ID - citeulike:1325557 L3 - citeulike-article-id:1325557 TI - Dissociable Neural Responses in Human Reward Systems JF - J. Neurosci. VL - 20 IS - 16 SP - 6159 EP - 6165 N2 - Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced. KW - fmri KW - globus_pallidus KW - hippocampus KW - penalties KW - rewards KW - striatum AU - Elliott, Rebecca AU - Friston, Karl AU - Dolan, Raymond PY - 2000/08/15/ UR - http://www.jneurosci.org/cgi/content/abstract/20/16/6159 ER -