Serotonin transporter genetic variation and the response of the human amygdala.

@article{citeulike:790690, abstract = {A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. We now report that individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity, as assessed by BOLD functional magnetic resonance imaging, in response to fearful stimuli compared with individuals homozygous for the long allele. These results demonstrate genetically driven variation in the response of brain regions underlying human emotional behavior and suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.}, address = {Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.}, author = {Hariri, A. R. and Mattay, V. S. and Tessitore, A. and Kolachana, B. and Fera, F. and Goldman, D. and Egan, M. F. and Weinberger, D. R. }, citeulike-article-id = {790690}, doi = {10.1126/science.1071829}, issn = {1095-9203}, journal = {Science}, keywords = {amygdala, fmri, genotype, imaging\_genomics, serotonin, serotonin\_polymorphism, serotonin\_transporter}, month = {July}, number = {5580}, pages = {400--403}, posted-at = {2007-06-15 16:52:44}, priority = {2}, title = {Serotonin transporter genetic variation and the response of the human amygdala.}, url = {http://dx.doi.org/10.1126/science.1071829}, volume = {297}, year = {2002} }

TY - JOUR ID - citeulike:790690 L3 - citeulike-article-id:790690 TI - Serotonin transporter genetic variation and the response of the human amygdala. JF - Science VL - 297 IS - 5580 SP - 400 EP - 403 AD - Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. SN - 1095-9203 N2 - A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. We now report that individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity, as assessed by BOLD functional magnetic resonance imaging, in response to fearful stimuli compared with individuals homozygous for the long allele. These results demonstrate genetically driven variation in the response of brain regions underlying human emotional behavior and suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele. KW - amygdala KW - fmri KW - genotype KW - imaging_genomics KW - serotonin KW - serotonin_polymorphism KW - serotonin_transporter AU - Hariri, AR AU - Mattay, VS AU - Tessitore, A AU - Kolachana, B AU - Fera, F AU - Goldman, D AU - Egan, MF AU - Weinberger, DR PY - 2002/07/19/ UR - http://dx.doi.org/10.1126/science.1071829 ER -