Mechanisms of specificity in protein phosphorylation Export

@article{citeulike:1407532, abstract = {A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of 700,000 potentially phosphorylatable residues. Multiple mechanisms have evolved that contribute to this exquisite specificity, including the structure of the catalytic site, local and distal interactions between the kinase and substrate, the formation of complexes with scaffolding and adaptor proteins that spatially regulate the kinase, systems-level competition between substrates, and error-correction mechanisms. The responsibility for the recognition of substrates by protein kinases appears to be distributed among a large number of independent, imperfect specificity mechanisms.}, author = {Ubersax, Jeffrey A. and Ferrell Jr, James E.}, citeulike-article-id = {1407532}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrm2203}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrm2203}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17585314}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17585314}, day = {01}, doi = {10.1038/nrm2203}, issn = {1471-0072}, journal = {Nature Reviews Molecular Cell Biology}, keywords = {kinase, phosphorylation}, month = {July}, number = {7}, pages = {530--541}, posted-at = {2008-07-09 04:38:26}, priority = {2}, publisher = {Nature Publishing Group}, title = {Mechanisms of specificity in protein phosphorylation}, url = {http://dx.doi.org/10.1038/nrm2203}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:1407532 L3 - citeulike-article-id:1407532 N2 - A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of 700,000 potentially phosphorylatable residues. Multiple mechanisms have evolved that contribute to this exquisite specificity, including the structure of the catalytic site, local and distal interactions between the kinase and substrate, the formation of complexes with scaffolding and adaptor proteins that spatially regulate the kinase, systems-level competition between substrates, and error-correction mechanisms. The responsibility for the recognition of substrates by protein kinases appears to be distributed among a large number of independent, imperfect specificity mechanisms. IS - 7 JF - Nature Reviews Molecular Cell Biology SN - 1471-0072 EP - 541 TI - Mechanisms of specificity in protein phosphorylation PB - Nature Publishing Group VL - 8 SP - 530 KW - kinase KW - phosphorylation AU - Ubersax, Jeffrey AU - Ferrell Jr, James PY - 2007/07/01/ UR - http://dx.doi.org/10.1038/nrm2203 ER -