High-throughput kinase profiling as a platform for drug discovery Export

@article{citeulike:2739378, author = {Goldstein, David M. and Gray, Nathanael S. and Zarrinkar, Patrick P.}, citeulike-article-id = {2739378}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrd2541}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrd2541}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18404149}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18404149}, comment = {This article makes the case that multi-kinases x multi-candidate inhibitors screens are much more informative than current single kinase x multi-compounds screens (screens which are directed against a single kinase). This not only allows to judge the degree to which compounds are specific to a kinase but may also lead to inhibitors that can target multiple kinase involved in different pathways (e.g. angiogenesis and cell cycle).}, doi = {10.1038/nrd2541}, journal = {Nat Rev Drug Discov}, keywords = {drug\_discovery, kinase}, month = {May}, number = {5}, pages = {391--397}, posted-at = {2008-05-05 01:08:39}, priority = {2}, publisher = {Nature Publishing Group}, title = {High-throughput kinase profiling as a platform for drug discovery}, url = {http://dx.doi.org/10.1038/nrd2541}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:2739378 L3 - citeulike-article-id:2739378 IS - 5 JF - Nat Rev Drug Discov EP - 397 TI - High-throughput kinase profiling as a platform for drug discovery PB - Nature Publishing Group VL - 7 SP - 391 KW - drug_discovery KW - kinase N1 - This article makes the case that multi-kinases x multi-candidate inhibitors screens are much more informative than current single kinase x multi-compounds screens (screens which are directed against a single kinase). This not only allows to judge the degree to which compounds are specific to a kinase but may also lead to inhibitors that can target multiple kinase involved in different pathways (e.g. angiogenesis and cell cycle). AU - Goldstein, David AU - Gray, Nathanael AU - Zarrinkar, Patrick PY - 2008/05// UR - http://dx.doi.org/10.1038/nrd2541 ER -