On the Contribution of Spatial Genome Organization to Cancerous Chromosome Translocations Export

@article{citeulike:3149391, abstract = {The formation of cancer translocations requires the physical interaction of the translocating chromosomes. It has been postulated that the nonrandom spatial organization of the genome within the cell nucleus contributes to determining the outcome of chromosomal translocation. Comparative analysis of the spatial arrangement of translocations partners and their frequency of translocation suggests that translocations occur preferentially among proximally positioned genome regions. This model makes predictions about mechanisms of translocations and the dynamic properties of genome regions in vivo. Elucidating the contribution of spatial genome organization to the formation of chromosome translocations is an integral part of understanding how translocations form in vivo and has provoked the interrogation of several fundamental aspects of genome cell biology, including tissue-specific differences in genome organization, dynamics of genomes in vivo, and the mechanisms that are determining genome organization in vivo. 10.1093/jncimonographs/lgn017}, author = {Soutoglou, Evi and Misteli, Tom}, citeulike-article-id = {3149391}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/jncimonographs/lgn017}, citeulike-linkout-1 = {http://jncimono.oxfordjournals.org/cgi/content/abstract/2008/39/16}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18647996}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18647996}, comment = {The 30Mb-separated RET and H4 loci are found in proximity in the nucleus and rearrange often, but only in thyroid tissues. This may apply to TMPRSS2-ERG (separated by 3Mb) ... and could be used as diagnostic. Close proximity may mean higher likelihood of rearrangement. Small molecules might be screen for loci separation activity. Of note, an induced DSB in a LINE recombines much more frequently with proximal LINEs. Challenges: finding factors that determine the position and the mobility of genome regions in vivo, and what the kinetics of finding a translocation partner and of formation of the actual translocation are. }, day = {1}, doi = {10.1093/jncimonographs/lgn017}, journal = {J Natl Cancer Inst Monogr}, keywords = {chromatin, chromosome\_organization}, month = {July}, number = {39}, pages = {16--19}, posted-at = {2008-08-31 01:22:17}, priority = {2}, title = {On the Contribution of Spatial Genome Organization to Cancerous Chromosome Translocations}, url = {http://dx.doi.org/10.1093/jncimonographs/lgn017}, volume = {2008}, year = {2008} }

TY - JOUR ID - citeulike:3149391 L3 - citeulike-article-id:3149391 N2 - The formation of cancer translocations requires the physical interaction of the translocating chromosomes. It has been postulated that the nonrandom spatial organization of the genome within the cell nucleus contributes to determining the outcome of chromosomal translocation. Comparative analysis of the spatial arrangement of translocations partners and their frequency of translocation suggests that translocations occur preferentially among proximally positioned genome regions. This model makes predictions about mechanisms of translocations and the dynamic properties of genome regions in vivo. Elucidating the contribution of spatial genome organization to the formation of chromosome translocations is an integral part of understanding how translocations form in vivo and has provoked the interrogation of several fundamental aspects of genome cell biology, including tissue-specific differences in genome organization, dynamics of genomes in vivo, and the mechanisms that are determining genome organization in vivo. 10.1093/jncimonographs/lgn017 IS - 39 JF - J Natl Cancer Inst Monogr EP - 19 TI - On the Contribution of Spatial Genome Organization to Cancerous Chromosome Translocations VL - 2008 SP - 16 KW - chromatin KW - chromosome_organization N1 - The 30Mb-separated RET and H4 loci are found in proximity in the nucleus and rearrange often, but only in thyroid tissues. This may apply to TMPRSS2-ERG (separated by 3Mb) ... and could be used as diagnostic. Close proximity may mean higher likelihood of rearrangement. Small molecules might be screen for loci separation activity. Of note, an induced DSB in a LINE recombines much more frequently with proximal LINEs. Challenges: finding factors that determine the position and the mobility of genome regions in vivo, and what the kinetics of finding a translocation partner and of formation of the actual translocation are. AU - Soutoglou, Evi AU - Misteli, Tom PY - 2008/07/01/ UR - http://dx.doi.org/10.1093/jncimonographs/lgn017 ER -