Ganglion Cell Adaptability: Does the Coupling of Horizontal Cells Play a Role?

@article{citeulike:3176980, abstract = {Background: The visual system can adjust itself to different visual environments. One of the most well known examples of this is the shift in spatial tuning that occurs in retinal ganglion cells with the change from night to day vision. This shift is thought to be produced by a change in the ganglion cell receptive field surround, mediated by a decrease in the coupling of horizontal cells. Methodology/Principal Findings: To test this hypothesis, we used a transgenic mouse line, a connexin57-deficient line, in which horizontal cell coupling was abolished. Measurements, both at the ganglion cell level and the level of behavioral performance, showed no differences between wild-type retinas and retinas with decoupled horizontal cells from connexin57-deficient mice. Conclusion/Significance: This analysis showed that the coupling and uncoupling of horizontal cells does not play a dominant role in spatial tuning and its adjustability to night and day light conditions. Instead, our data suggest that another mechanism, likely arising in the inner retina, must be responsible.}, author = {Dedek, Karin and Pandarinath, Chethan and Alam, Nazia M. and Wellershaus, Kerstin and Schubert, Timm and Willecke, Klaus and Prusky, Glen T. and Weiler, Reto and Nirenberg, Sheila}, citeulike-article-id = {3176980}, doi = {10.1371/journal.pone.0001714}, journal = {PLoS ONE}, keywords = {neuroscience, nirenberg, weill}, month = {March}, number = {3}, pages = {e1714+}, posted-at = {2008-08-31 19:56:19}, priority = {2}, publisher = {Public Library of Science}, title = {Ganglion Cell Adaptability: Does the Coupling of Horizontal Cells Play a Role?}, url = {http://dx.doi.org/10.1371/journal.pone.0001714}, volume = {3}, year = {2008} }

TY - JOUR ID - citeulike:3176980 L3 - citeulike-article-id:3176980 N2 - Background: The visual system can adjust itself to different visual environments. One of the most well known examples of this is the shift in spatial tuning that occurs in retinal ganglion cells with the change from night to day vision. This shift is thought to be produced by a change in the ganglion cell receptive field surround, mediated by a decrease in the coupling of horizontal cells. Methodology/Principal Findings: To test this hypothesis, we used a transgenic mouse line, a connexin57-deficient line, in which horizontal cell coupling was abolished. Measurements, both at the ganglion cell level and the level of behavioral performance, showed no differences between wild-type retinas and retinas with decoupled horizontal cells from connexin57-deficient mice. Conclusion/Significance: This analysis showed that the coupling and uncoupling of horizontal cells does not play a dominant role in spatial tuning and its adjustability to night and day light conditions. Instead, our data suggest that another mechanism, likely arising in the inner retina, must be responsible. IS - 3 JF - PLoS ONE TI - Ganglion Cell Adaptability: Does the Coupling of Horizontal Cells Play a Role? PB - Public Library of Science VL - 3 SP - e1714 KW - neuroscience KW - nirenberg KW - weill AU - Dedek, Karin AU - Pandarinath, Chethan AU - Alam, Nazia AU - Wellershaus, Kerstin AU - Schubert, Timm AU - Willecke, Klaus AU - Prusky, Glen AU - Weiler, Reto AU - Nirenberg, Sheila PY - 2008/03/05/ UR - http://dx.doi.org/10.1371/journal.pone.0001714 ER -