Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function Export

@article{citeulike:3343439, abstract = {The purpose of the workshop was to identify still obscure or novel cellular components of the lung, to determine cell function in lung development and in health that impacts on disease, and to decide promising avenues for future research to extract and phenotype these cells. Since robust technologies are now available to identify, sort, purify, culture, and phenotype cells, progress is now within sight to unravel the origins and functional capabilities of lung cells in developmental stages and in disease. The Workshop's agenda was to first discuss the lung's embryologic development, including progenitor and stem cells, and then assess the functional and structural cells in three main compartments of the lung: (1) airway cells in bronchial and bronchiolar epithelium and bronchial glands (basal, secretory, ciliated, Clara, and neuroendocrine cells); (2) alveolar unit cells (Type 1 cells, Type 2 cells, and fibroblasts in the interstitium); and (3) pulmonary vascular cells (endothelial cells from different vascular structures, smooth muscle cells, and adventitial fibroblasts). The main recommendations were to: (1) characterize with better cell markers, both surface and nonsurface, the various cells within the lung, including progenitor cells and stem cells; (2) obtain more knowledge about gene expression in specific cell types in health and disease, which will provide insights into biological and pathologic processes; (3) develop more methodologies for cell culture, isolation, sorting, co-culture, and immortalization; and (4) promote tissue banks to facilitate the procurement of tissue from normal and from diseased lung for analysis at all levels. 10.1513/pats.200803-025HR}, author = {Franks, Teri J. and Colby, Thomas V. and Travis, William D. and Tuder, Rubin M. and Reynolds, Herbert Y. and Brody, Arnold R. and Cardoso, Wellington V. and Crystal, Ronald G. and Drake, Christopher J. and Engelhardt, John and Frid, Maria and Herzog, Erica and Mason, Robert and Phan, Sem H. and Randell, Scott H. and Rose, Mary C. and Stevens, Troy and Serge, Julie and Sunday, Mary E. and Voynow, Judith A. and Weinstein, Brant M. and Whitsett, Jeffrey and Williams, Mary C.}, citeulike-article-id = {3343439}, citeulike-linkout-0 = {http://dx.doi.org/10.1513/pats.200803-025HR}, citeulike-linkout-1 = {http://pats.atsjournals.org/cgi/content/abstract/5/7/763}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18757314}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18757314}, comment = {40 cell types in lung. ---=note-separator=--- 40 different cell types in human respiratory tract.}, day = {15}, doi = {10.1513/pats.200803-025HR}, journal = {Proc Am Thorac Soc}, keywords = {crystal, lung, review}, month = {September}, number = {7}, pages = {763--766}, posted-at = {2008-09-27 01:24:23}, priority = {0}, title = {Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function}, url = {http://dx.doi.org/10.1513/pats.200803-025HR}, volume = {5}, year = {2008} }

TY - JOUR ID - citeulike:3343439 L3 - citeulike-article-id:3343439 N2 - The purpose of the workshop was to identify still obscure or novel cellular components of the lung, to determine cell function in lung development and in health that impacts on disease, and to decide promising avenues for future research to extract and phenotype these cells. Since robust technologies are now available to identify, sort, purify, culture, and phenotype cells, progress is now within sight to unravel the origins and functional capabilities of lung cells in developmental stages and in disease. The Workshop's agenda was to first discuss the lung's embryologic development, including progenitor and stem cells, and then assess the functional and structural cells in three main compartments of the lung: (1) airway cells in bronchial and bronchiolar epithelium and bronchial glands (basal, secretory, ciliated, Clara, and neuroendocrine cells); (2) alveolar unit cells (Type 1 cells, Type 2 cells, and fibroblasts in the interstitium); and (3) pulmonary vascular cells (endothelial cells from different vascular structures, smooth muscle cells, and adventitial fibroblasts). The main recommendations were to: (1) characterize with better cell markers, both surface and nonsurface, the various cells within the lung, including progenitor cells and stem cells; (2) obtain more knowledge about gene expression in specific cell types in health and disease, which will provide insights into biological and pathologic processes; (3) develop more methodologies for cell culture, isolation, sorting, co-culture, and immortalization; and (4) promote tissue banks to facilitate the procurement of tissue from normal and from diseased lung for analysis at all levels. 10.1513/pats.200803-025HR IS - 7 JF - Proc Am Thorac Soc EP - 766 TI - Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function VL - 5 SP - 763 KW - crystal KW - lung KW - review N1 - 40 cell types in lung. N1 - 40 different cell types in human respiratory tract. AU - Franks, Teri AU - Colby, Thomas AU - Travis, William AU - Tuder, Rubin AU - Reynolds, Herbert AU - Brody, Arnold AU - Cardoso, Wellington AU - Crystal, Ronald AU - Drake, Christopher AU - Engelhardt, John AU - Frid, Maria AU - Herzog, Erica AU - Mason, Robert AU - Phan, Sem AU - Randell, Scott AU - Rose, Mary AU - Stevens, Troy AU - Serge, Julie AU - Sunday, Mary AU - Voynow, Judith AU - Weinstein, Brant AU - Whitsett, Jeffrey AU - Williams, Mary PY - 2008/09/15/ UR - http://dx.doi.org/10.1513/pats.200803-025HR ER -