Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Export

@article{citeulike:2323279, abstract = {BACKGROUND: Aging in men is characterized by a progressive decline in levels of anabolic hormones, such as testosterone, insulinlike growth factor 1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S). We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders. METHODS: Testosterone, IGF-1, DHEA-S, and demographic features were evaluated in a representative sample of 410 men 65 years and older enrolled in the Aging in the Chianti Area (InCHIANTI) study. A total of 126 men died during the 6-year follow-up. Thresholds for lowest-quartile definitions were 70 ng/dL (to convert to nanomoles per liter, multiply by 0.0347) for bioavailable testosterone, 63.9 ng/mL (to convert to nanomoles per liter, multiply by 0.131) for total IGF-1, and 50 microg/dL (to convert to micromoles per liter, multiply by 0.027) for DHEA-S. Men were divided into 4 groups: no hormone in the lowest quartile (reference) and 1, 2, and 3 hormones in the lowest quartiles. Kaplan-Meier survival and Cox proportional hazards models adjusted for confounders were used in the analysis. RESULTS: Compared with men with levels of all 3 hormones above the lowest quartiles, having 1, 2, and 3 dysregulated hormones was associated with hazard ratios for mortality of 1.47 (95\% confidence interval [CI], 0.88-2.44), 1.85 (95\% CI, 1.04-3.30), and 2.29 (95\% CI, 1.12-4.68), respectively (test for trend, P <.001). In the fully adjusted analysis, only men with 3 anabolic hormone deficiencies had a significant increase in mortality (hazard ratio, 2.44; 95\% CI, 1.09-5.46 (test for trend, P <.001). CONCLUSIONS: Age-associated decline in anabolic hormone levels is a strong independent predictor of mortality in older men. Having multiple hormonal deficiencies rather than a deficiency in a single anabolic hormone is a robust biomarker of health status in older persons.}, address = {National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA.}, author = {Maggio, M. and Lauretani, F. and Ceda, G. P. and Bandinelli, S. and Ling, S. M. and Metter, E. J. and Artoni, A. and Carassale, L. and Cazzato, A. and Ceresini, G. and Guralnik, J. M. and Basaria, S. and Valenti, G. and Ferrucci, L.}, citeulike-article-id = {2323279}, citeulike-linkout-0 = {http://dx.doi.org/10.1001/archinte.167.20.2249}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17998499}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17998499}, comment = {Es muy notoria el efecto aditivo sobre mortalidad de las deficiencias hormonales de T, GH \& DHEA}, day = {12}, doi = {10.1001/archinte.167.20.2249}, issn = {0003-9926}, journal = {Arch Intern Med}, keywords = {aging, androgen, mortality, risk}, month = {November}, number = {20}, pages = {2249--2254}, posted-at = {2008-02-02 16:28:18}, priority = {2}, title = {Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study.}, url = {http://dx.doi.org/10.1001/archinte.167.20.2249}, volume = {167}, year = {2007} }

TY - JOUR ID - citeulike:2323279 L3 - citeulike-article-id:2323279 N2 - BACKGROUND: Aging in men is characterized by a progressive decline in levels of anabolic hormones, such as testosterone, insulinlike growth factor 1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S). We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders. METHODS: Testosterone, IGF-1, DHEA-S, and demographic features were evaluated in a representative sample of 410 men 65 years and older enrolled in the Aging in the Chianti Area (InCHIANTI) study. A total of 126 men died during the 6-year follow-up. Thresholds for lowest-quartile definitions were 70 ng/dL (to convert to nanomoles per liter, multiply by 0.0347) for bioavailable testosterone, 63.9 ng/mL (to convert to nanomoles per liter, multiply by 0.131) for total IGF-1, and 50 microg/dL (to convert to micromoles per liter, multiply by 0.027) for DHEA-S. Men were divided into 4 groups: no hormone in the lowest quartile (reference) and 1, 2, and 3 hormones in the lowest quartiles. Kaplan-Meier survival and Cox proportional hazards models adjusted for confounders were used in the analysis. RESULTS: Compared with men with levels of all 3 hormones above the lowest quartiles, having 1, 2, and 3 dysregulated hormones was associated with hazard ratios for mortality of 1.47 (95% confidence interval [CI], 0.88-2.44), 1.85 (95% CI, 1.04-3.30), and 2.29 (95% CI, 1.12-4.68), respectively (test for trend, P <.001). In the fully adjusted analysis, only men with 3 anabolic hormone deficiencies had a significant increase in mortality (hazard ratio, 2.44; 95% CI, 1.09-5.46 (test for trend, P <.001). CONCLUSIONS: Age-associated decline in anabolic hormone levels is a strong independent predictor of mortality in older men. Having multiple hormonal deficiencies rather than a deficiency in a single anabolic hormone is a robust biomarker of health status in older persons. IS - 20 JF - Arch Intern Med SN - 0003-9926 AD - National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA. EP - 2254 TI - Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. VL - 167 SP - 2249 KW - aging KW - androgen KW - mortality KW - risk N1 - Es muy notoria el efecto aditivo sobre mortalidad de las deficiencias hormonales de T, GH & DHEA AU - Maggio, M AU - Lauretani, F AU - Ceda, GP AU - Bandinelli, S AU - Ling, SM AU - Metter, EJ AU - Artoni, A AU - Carassale, L AU - Cazzato, A AU - Ceresini, G AU - Guralnik, JM AU - Basaria, S AU - Valenti, G AU - Ferrucci, L PY - 2007/11/12/ UR - http://dx.doi.org/10.1001/archinte.167.20.2249 ER -