The Association Between the FTO Gene and Fat Mass in Humans Develops by the Postnatal Age of Two Weeks. Export

@article{citeulike:2394905, abstract = {Objective: Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates. Design: Cross-sectional, hospital-based study. Patients: Two hundred and thirty-four full-term, healthy newborns [122 girls and 112 boys; gestational age (mean, range): 39.0 (37.0-42.0) w, birth weight: 3.2 (1.9-4.2) Kg]. Methods: Cord-blood insulin, IGF-I, IGFBP-1, adiponectin and visfatin, measured by specific immunoassays. Body composition, assessed by dual energy X-ray absorptiometry at approximately 13 d (range, 9-20 d). Genotyping of rs9939609 by retriction fragment length polymorphism analysis. Results: The rs9939609 SNP in FTO was not associated with birth weight; however it was associated with serum visfatin (p<0.001), with weight and ponderal index at age 2 weeks (p<0.05), and with total, truncal and abdominal fat (p<0.05 to p=0.01), so that AA homozygotes had 37\% higher plasma visfatin concentration and 17\%, 20\% and 17\% higher total, truncal and abdominal fat mass, respectively, than T-carrier neonates. Conclusion: Our findings support a role of the common rs9939609 SNP in FTO gene in the early stages of fat accretion in humans, and disclose novel associations between this SNP and both serum visfatin and abdominal fat mass in neonates.}, address = {Diabetes, Endocrinology \& Nutrition Unit, Dr. Josep Trueta Hospital, 17007 Girona, Spain; Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, United Kingdom; Endocrinology Unit and Endocrine Laboratory, Sant Joan de D\'{e}u Children's Hospital, University of Barcelona, 08950 Esplugues, Barcelona, Spain; Department of Woman \& Child, University of Leuven, 3000 Leuven, Belgium.}, author = {L\'{o}pez-Bermejo, Abel and Petry, Clive J J. and D\'{\i}az, Marta and Sebastiani, Giorgia and de Zegher, Francis and Dunger, David B B. and Ib\'{a}\~{n}ez, Lourdes}, citeulike-article-id = {2394905}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2007-2343}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18252780}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18252780}, day = {5}, doi = {10.1210/jc.2007-2343}, issn = {0021-972X}, journal = {J Clin Endocrinol Metab}, keywords = {adiposity, bmi, molecular, obesity}, month = {February}, posted-at = {2008-02-18 16:12:30}, priority = {2}, title = {The Association Between the FTO Gene and Fat Mass in Humans Develops by the Postnatal Age of Two Weeks.}, url = {http://dx.doi.org/10.1210/jc.2007-2343}, year = {2008} }

TY - JOUR ID - citeulike:2394905 L3 - citeulike-article-id:2394905 N2 - Objective: Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates. Design: Cross-sectional, hospital-based study. Patients: Two hundred and thirty-four full-term, healthy newborns [122 girls and 112 boys; gestational age (mean, range): 39.0 (37.0-42.0) w, birth weight: 3.2 (1.9-4.2) Kg]. Methods: Cord-blood insulin, IGF-I, IGFBP-1, adiponectin and visfatin, measured by specific immunoassays. Body composition, assessed by dual energy X-ray absorptiometry at approximately 13 d (range, 9-20 d). Genotyping of rs9939609 by retriction fragment length polymorphism analysis. Results: The rs9939609 SNP in FTO was not associated with birth weight; however it was associated with serum visfatin (p<0.001), with weight and ponderal index at age 2 weeks (p<0.05), and with total, truncal and abdominal fat (p<0.05 to p=0.01), so that AA homozygotes had 37% higher plasma visfatin concentration and 17%, 20% and 17% higher total, truncal and abdominal fat mass, respectively, than T-carrier neonates. Conclusion: Our findings support a role of the common rs9939609 SNP in FTO gene in the early stages of fat accretion in humans, and disclose novel associations between this SNP and both serum visfatin and abdominal fat mass in neonates. JF - J Clin Endocrinol Metab SN - 0021-972X AD - Diabetes, Endocrinology & Nutrition Unit, Dr. Josep Trueta Hospital, 17007 Girona, Spain; Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, United Kingdom; Endocrinology Unit and Endocrine Laboratory, Sant Joan de Déu Children's Hospital, University of Barcelona, 08950 Esplugues, Barcelona, Spain; Department of Woman & Child, University of Leuven, 3000 Leuven, Belgium. TI - The Association Between the FTO Gene and Fat Mass in Humans Develops by the Postnatal Age of Two Weeks. KW - adiposity KW - bmi KW - molecular KW - obesity AU - López-Bermejo, Abel AU - Petry, Clive J AU - Díaz, Marta AU - Sebastiani, Giorgia AU - de Zegher, Francis AU - Dunger, David B AU - Ibáñez, Lourdes PY - 2008/02/05/ UR - http://dx.doi.org/10.1210/jc.2007-2343 ER -