Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels. Export

@article{citeulike:2430366, abstract = {OBJECTIVE: An unknown proportion of transsexual women (defined as post-operative male-to-female transsexuals on oestrogen replacement) experience hypoactive sexual desire disorder (HSDD). It has been suggested that the absence of ovarian androgen production together with oestrogen treatment-related increase in sex hormone-binding globulin (SHBG) levels could be leading to HSDD, due to low levels of biologically available testosterone. This study wishes to document the HSDD prevalence among transsexual women and the possible association to androgen levels. DESIGN: Cross-sectional study. METHODS: Transsexual women (n=62) and a control group of ovulating women (n=30) participated in this study. Questionnaires measuring sexual desire (sexual desire inventory) and relationship and sexual satisfaction (Maudsley Marital Questionnaire) were completed. Serum levels of total testosterone, LH and SHBG were measured in blood samples obtained at random in transsexual women and in the early follicular phase in ovulating women. RESULTS: The transsexual group had lower levels of total and calculated free testosterone (both P<0.001) than the ovulating women. HSDD was reported in 34\% of the transsexual and 23\% of the ovulating women (P=0.30). Both groups reported similar levels of sexual desire (P=0.97). For transsexual women, no significant correlation was found between sexual desire and total (P=0.64) or free testosterone (P=0.82). In ovulating women, these correlations were significant (P=0.006, resp. P=0.003). CONCLUSIONS: HSDD is reported in one-third of transsexual women. This prevalence is not substantially different from controls, despite markedly lower (free) testosterone levels, which argues against a major role of testosterone in this specific group.}, author = {Elaut, Els and De Cuypere, Griet and De Sutter, Petra and Gijs, Luk and Van Trotsenburg, Michael and Heylens, Gunter and Kaufman, Jean-Marc M. and Rubens, Robert and T'sjoen, Guy}, citeulike-article-id = {2430366}, citeulike-linkout-0 = {http://dx.doi.org/10.1530/EJE-07-0511}, citeulike-linkout-1 = {http://www.eje-online.org/cgi/content/abstract/158/3/393}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18299474}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18299474}, day = {1}, doi = {10.1530/EJE-07-0511}, issn = {1479-683X}, journal = {European journal of endocrinology / European Federation of Endocrine Societies}, keywords = {femalegonadal, testosterone}, month = {March}, number = {3}, pages = {393--399}, posted-at = {2008-02-26 17:02:36}, priority = {2}, title = {Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels.}, url = {http://dx.doi.org/10.1530/EJE-07-0511}, volume = {158}, year = {2008} }

TY - JOUR ID - citeulike:2430366 L3 - citeulike-article-id:2430366 N2 - OBJECTIVE: An unknown proportion of transsexual women (defined as post-operative male-to-female transsexuals on oestrogen replacement) experience hypoactive sexual desire disorder (HSDD). It has been suggested that the absence of ovarian androgen production together with oestrogen treatment-related increase in sex hormone-binding globulin (SHBG) levels could be leading to HSDD, due to low levels of biologically available testosterone. This study wishes to document the HSDD prevalence among transsexual women and the possible association to androgen levels. DESIGN: Cross-sectional study. METHODS: Transsexual women (n=62) and a control group of ovulating women (n=30) participated in this study. Questionnaires measuring sexual desire (sexual desire inventory) and relationship and sexual satisfaction (Maudsley Marital Questionnaire) were completed. Serum levels of total testosterone, LH and SHBG were measured in blood samples obtained at random in transsexual women and in the early follicular phase in ovulating women. RESULTS: The transsexual group had lower levels of total and calculated free testosterone (both P<0.001) than the ovulating women. HSDD was reported in 34% of the transsexual and 23% of the ovulating women (P=0.30). Both groups reported similar levels of sexual desire (P=0.97). For transsexual women, no significant correlation was found between sexual desire and total (P=0.64) or free testosterone (P=0.82). In ovulating women, these correlations were significant (P=0.006, resp. P=0.003). CONCLUSIONS: HSDD is reported in one-third of transsexual women. This prevalence is not substantially different from controls, despite markedly lower (free) testosterone levels, which argues against a major role of testosterone in this specific group. IS - 3 JF - European journal of endocrinology / European Federation of Endocrine Societies SN - 1479-683X EP - 399 TI - Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels. VL - 158 SP - 393 KW - femalegonadal KW - testosterone AU - Elaut, Els AU - De Cuypere, Griet AU - De Sutter, Petra AU - Gijs, Luk AU - Van Trotsenburg, Michael AU - Heylens, Gunter AU - Kaufman, Jean-Marc AU - Rubens, Robert AU - T'sjoen, Guy PY - 2008/03/01/ UR - http://dx.doi.org/10.1530/EJE-07-0511 ER -