Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men Export

@article{citeulike:6016968, abstract = {Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo.Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA.Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men.Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined. 10.1210/jc.2009-1450}, author = {Moverare-Skrtic, Sofia and Svensson, Johan and Karlsson, Magnus K. and Orwoll, Eric and Ljunggren, Osten and Mellstrom, Dan and Ohlsson, Claes}, citeulike-article-id = {6016968}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2009-1450}, citeulike-linkout-1 = {http://jcem.endojournals.org/content/jc.2009-1450v1/.abstract}, citeulike-linkout-2 = {http://jcem.endojournals.org/content/jc.2009-1450v1/.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19846733}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19846733}, day = {21}, doi = {10.1210/jc.2009-1450}, journal = {J Clin Endocrinol Metab}, keywords = {growth-factors, igf, physiology}, month = {October}, pages = {jc.2009-1450+}, posted-at = {2009-10-27 22:29:17}, priority = {2}, title = {Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men}, url = {http://dx.doi.org/10.1210/jc.2009-1450}, year = {2009} }

TY - JOUR ID - citeulike:6016968 L3 - citeulike-article-id:6016968 N2 - Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo.Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA.Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men.Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined. 10.1210/jc.2009-1450 JF - J Clin Endocrinol Metab TI - Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men SP - jc.2009-1450 KW - growth-factors KW - igf KW - physiology AU - Moverare-Skrtic, Sofia AU - Svensson, Johan AU - Karlsson, Magnus AU - Orwoll, Eric AU - Ljunggren, Osten AU - Mellstrom, Dan AU - Ohlsson, Claes PY - 2009/10/21/ UR - http://dx.doi.org/10.1210/jc.2009-1450 ER -