Electrostatic Free Energy Landscapes for DNA Helix Bending Export

@article{citeulike:2600210, abstract = {Nucleic acids are highly charged polyanionic molecules; thus, the ionic conditions are crucial for nucleic acid structural changes such as bending. We use the tightly bound ion theory, which explicitly accounts for the correlation and ensemble effects for counterions, to calculate the electrostatic free energy landscapes for DNA helix bending. The electrostatic free energy landscapes show that DNA bending energy is strongly dependent on ion concentration, valency, and size. In a Na+ solution, DNA bending is electrostatically unfavorable because of the strong charge repulsion on backbone. With the increase of the Na+ concentration, the electrostatic bending repulsion is reduced and thus the bending becomes less unfavorable. In contrast, in an Mg2+ solution, ion correlation induces a possible attractive force between the different parts of the helical strands, resulting in bending. The electrostatically most favorable and unfavorable bending directions are toward the major and minor grooves, respectively. Decreasing the size of the divalent ions enhances the electrostatic bending attraction, causing an increased bending angle, and shifts the most favorable bending to the direction toward the minor groove. The microscopic analysis on ion-binding distribution reveals that the divalent ion-induced helix bending attraction may come from the correlated distribution of the ions across the grooves in the bending direction. 10.1529/biophysj.107.122366}, author = {Tan, Zhi-Jie and Chen, Shi-Jie}, citeulike-article-id = {2600210}, citeulike-linkout-0 = {http://dx.doi.org/10.1529/biophysj.107.122366}, citeulike-linkout-1 = {http://www.biophysj.org/cgi/content/abstract/94/8/3137}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18192348}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18192348}, day = {15}, doi = {10.1529/biophysj.107.122366}, journal = {Biophys. J.}, keywords = {dna, dna\_bend, dna\_electrostatics}, month = {April}, number = {8}, pages = {3137--3149}, posted-at = {2008-11-10 21:18:28}, priority = {2}, title = {Electrostatic Free Energy Landscapes for DNA Helix Bending}, url = {http://dx.doi.org/10.1529/biophysj.107.122366}, volume = {94}, year = {2008} }

TY - JOUR ID - citeulike:2600210 L3 - citeulike-article-id:2600210 N2 - Nucleic acids are highly charged polyanionic molecules; thus, the ionic conditions are crucial for nucleic acid structural changes such as bending. We use the tightly bound ion theory, which explicitly accounts for the correlation and ensemble effects for counterions, to calculate the electrostatic free energy landscapes for DNA helix bending. The electrostatic free energy landscapes show that DNA bending energy is strongly dependent on ion concentration, valency, and size. In a Na+ solution, DNA bending is electrostatically unfavorable because of the strong charge repulsion on backbone. With the increase of the Na+ concentration, the electrostatic bending repulsion is reduced and thus the bending becomes less unfavorable. In contrast, in an Mg2+ solution, ion correlation induces a possible attractive force between the different parts of the helical strands, resulting in bending. The electrostatically most favorable and unfavorable bending directions are toward the major and minor grooves, respectively. Decreasing the size of the divalent ions enhances the electrostatic bending attraction, causing an increased bending angle, and shifts the most favorable bending to the direction toward the minor groove. The microscopic analysis on ion-binding distribution reveals that the divalent ion-induced helix bending attraction may come from the correlated distribution of the ions across the grooves in the bending direction. 10.1529/biophysj.107.122366 IS - 8 JF - Biophys. J. EP - 3149 TI - Electrostatic Free Energy Landscapes for DNA Helix Bending VL - 94 SP - 3137 KW - dna KW - dna_bend KW - dna_electrostatics AU - Tan, Zhi-Jie AU - Chen, Shi-Jie PY - 2008/04/15/ UR - http://dx.doi.org/10.1529/biophysj.107.122366 ER -