Asymmetric lateral distribution of unshielded phosphate groups in nucleosomal DNA and its role in DNA bending Export

@article{citeulike:3501822, abstract = {We suggest that an asymmetric charge neutralization of DNA phosphate groups produces part of the driving force for nucleosome folding. In nucleosome core particle DNA, many of the phosphate groups are neutralized by histones, and a lateral alignment of these histones along the core DNA has been demonstrated [Mirzabekov A. D., Shick, V. V., Belyavsky, A. V. \& Bavykin, S. G. (1978) Proc. Natl. Acad. Sci. USA 75, 4184--4189]. Histones appear to shield DNA phosphatases asymmetrically at one side of the surface of the DNA double helix along all its length inside the core. The external side of the DNA helix remains unneutralized. The electrostatic repulsion between negatively charged unneutralized phosphates may fold the nucleosomal DNA towards the side occupied by histones.}, author = {Mirzabekov, A. D. and Rich, A.}, citeulike-article-id = {3501822}, citeulike-linkout-0 = {http://www.pnas.org/content/76/3/1118.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/76/3/1118.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/286297}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=286297}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {dna\_bend}, month = {March}, number = {3}, pages = {1118--1121}, posted-at = {2008-11-10 21:12:16}, priority = {2}, title = {Asymmetric lateral distribution of unshielded phosphate groups in nucleosomal DNA and its role in DNA bending}, url = {http://www.pnas.org/content/76/3/1118.abstract}, volume = {76}, year = {1979} }

TY - JOUR ID - citeulike:3501822 L3 - citeulike-article-id:3501822 N2 - We suggest that an asymmetric charge neutralization of DNA phosphate groups produces part of the driving force for nucleosome folding. In nucleosome core particle DNA, many of the phosphate groups are neutralized by histones, and a lateral alignment of these histones along the core DNA has been demonstrated [Mirzabekov A. D., Shick, V. V., Belyavsky, A. V. & Bavykin, S. G. (1978) Proc. Natl. Acad. Sci. USA 75, 4184--4189]. Histones appear to shield DNA phosphatases asymmetrically at one side of the surface of the DNA double helix along all its length inside the core. The external side of the DNA helix remains unneutralized. The electrostatic repulsion between negatively charged unneutralized phosphates may fold the nucleosomal DNA towards the side occupied by histones. IS - 3 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 1121 TI - Asymmetric lateral distribution of unshielded phosphate groups in nucleosomal DNA and its role in DNA bending VL - 76 SP - 1118 KW - dna_bend AU - Mirzabekov, AD AU - Rich, A PY - 1979/03// UR - http://www.pnas.org/content/76/3/1118.abstract ER -