The physics of chromatin Export

@article{citeulike:3840855, abstract = {Recent progress has been made in the understanding of the physical properties of chromatin--the dense complex of DNA and histone proteins that occupies the nuclei of plant and animal cells. Here I will focus on the two lowest levels of the hierarchy of DNA folding into the chromatin complex. (i) The nucleosome, the chromatin repeating unit consisting of a globular aggregate of eight histone proteins with the DNA wrapped around it: its overcharging, the DNA unwrapping transition, the 'sliding' of the octamer along the DNA. (ii) The 30 nm chromatin fibre, the necklace-like structure of nucleosomes connected via linker DNA: its geometry, its mechanical properties under stretching and its response to changing ionic conditions. I will stress that chromatin combines two seemingly contradictory features: (1) high compaction of DNA within the nuclear envelope and, at the same time, (2) accessibility to genes, promoter regions and gene regulatory sequences.}, author = {Schiessel, Helmut}, citeulike-article-id = {3840855}, citeulike-linkout-0 = {http://dx.doi.org/10.1088/0953-8984/15/19/203}, doi = {10.1088/0953-8984/15/19/203}, journal = {Journal of Physics: Condensed Matter}, keywords = {higher\_order\_chromatin, nucleosome, nucleosome\_stability}, number = {19}, pages = {R699--R774}, posted-at = {2009-01-02 01:36:52}, priority = {2}, title = {The physics of chromatin}, url = {http://dx.doi.org/10.1088/0953-8984/15/19/203}, volume = {15}, year = {2003} }

TY - JOUR ID - citeulike:3840855 L3 - citeulike-article-id:3840855 N2 - Recent progress has been made in the understanding of the physical properties of chromatin--the dense complex of DNA and histone proteins that occupies the nuclei of plant and animal cells. Here I will focus on the two lowest levels of the hierarchy of DNA folding into the chromatin complex. (i) The nucleosome, the chromatin repeating unit consisting of a globular aggregate of eight histone proteins with the DNA wrapped around it: its overcharging, the DNA unwrapping transition, the 'sliding' of the octamer along the DNA. (ii) The 30 nm chromatin fibre, the necklace-like structure of nucleosomes connected via linker DNA: its geometry, its mechanical properties under stretching and its response to changing ionic conditions. I will stress that chromatin combines two seemingly contradictory features: (1) high compaction of DNA within the nuclear envelope and, at the same time, (2) accessibility to genes, promoter regions and gene regulatory sequences. IS - 19 JF - Journal of Physics: Condensed Matter EP - R774 TI - The physics of chromatin VL - 15 SP - R699 KW - higher_order_chromatin KW - nucleosome KW - nucleosome_stability AU - Schiessel, Helmut PY - 2003/// UR - http://dx.doi.org/10.1088/0953-8984/15/19/203 ER -