Lie-Specific Involvement of Dorsolateral Prefrontal Cortex in Deception. Export

@article{citeulike:1411183, abstract = {Lies are intentional distortions of event knowledge. No experimental data are available on manipulating lying processes. To address this issue, we stimulated the dorsolateral prefrontal cortex (DLPFC) using transcranial direct current stimulation (tDCS). Fifteen healthy volunteers were tested before and after tDCS (anodal, cathodal, and sham). Two types of truthful (truthful selected: TS; truthful unselected: TU) and deceptive (lie selected: LS; lie unselected: LU) responses were evaluated using a computer-controlled task. Reaction times (RTs) and accuracy were collected and used as dependent variables. In the baseline task, the RT was significantly longer for lie responses than for true responses ([mean +/- standard error] 1153.4 +/- 42.0 ms vs. 1039.6 +/- 36.6 ms; F(1,14) = 27.25, P = 0.00013). At baseline, RT for selected pictures was significantly shorter than RT for unselected pictures (1051.26 +/- 39.0 ms vs. 1141.76 +/- 41.1 ms; F(1,14) = 34.85, P = 0.00004). Whereas after cathodal and sham stimulation, lie responses remained unchanged (cathodal 5.26 +/- 2.7\%; sham 5.66 +/- 3.6\%), after anodal tDCS, RTs significantly increased but did so only for LS responses (16.86 +/- 5.0\%; P = 0.002). These findings show that manipulation of brain function with DLPFC tDCS specifically influences experimental deception and that distinctive neural mechanisms underlie different types of lies.}, address = {Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Italy.}, author = {Priori, Alberto and Mameli, F and Cogiamanian, F and Marceglia, S and Tiriticco, M and Mrakic-Sposta, S and Ferrucci, R and Zago, S and Polezzi, D and Sartori, G}, citeulike-article-id = {1411183}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/cercor/bhm088}, citeulike-linkout-1 = {http://cercor.oxfordjournals.org/cgi/content/abstract/18/2/451}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17584853}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17584853}, day = {21}, doi = {10.1093/cercor/bhm088}, issn = {1047-3211}, journal = {Cereb Cortex}, keywords = {deception, dlpfc, jc-cercor, lying}, month = {June}, posted-at = {2008-02-26 15:26:10}, priority = {2}, title = {Lie-Specific Involvement of Dorsolateral Prefrontal Cortex in Deception.}, url = {http://dx.doi.org/10.1093/cercor/bhm088}, year = {2007} }

TY - JOUR ID - citeulike:1411183 L3 - citeulike-article-id:1411183 N2 - Lies are intentional distortions of event knowledge. No experimental data are available on manipulating lying processes. To address this issue, we stimulated the dorsolateral prefrontal cortex (DLPFC) using transcranial direct current stimulation (tDCS). Fifteen healthy volunteers were tested before and after tDCS (anodal, cathodal, and sham). Two types of truthful (truthful selected: TS; truthful unselected: TU) and deceptive (lie selected: LS; lie unselected: LU) responses were evaluated using a computer-controlled task. Reaction times (RTs) and accuracy were collected and used as dependent variables. In the baseline task, the RT was significantly longer for lie responses than for true responses ([mean +/- standard error] 1153.4 +/- 42.0 ms vs. 1039.6 +/- 36.6 ms; F(1,14) = 27.25, P = 0.00013). At baseline, RT for selected pictures was significantly shorter than RT for unselected pictures (1051.26 +/- 39.0 ms vs. 1141.76 +/- 41.1 ms; F(1,14) = 34.85, P = 0.00004). Whereas after cathodal and sham stimulation, lie responses remained unchanged (cathodal 5.26 +/- 2.7%; sham 5.66 +/- 3.6%), after anodal tDCS, RTs significantly increased but did so only for LS responses (16.86 +/- 5.0%; P = 0.002). These findings show that manipulation of brain function with DLPFC tDCS specifically influences experimental deception and that distinctive neural mechanisms underlie different types of lies. JF - Cereb Cortex SN - 1047-3211 AD - Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Italy. TI - Lie-Specific Involvement of Dorsolateral Prefrontal Cortex in Deception. KW - deception KW - dlpfc KW - jc-cercor KW - lying AU - Priori, Alberto AU - Mameli, F AU - Cogiamanian, F AU - Marceglia, S AU - Tiriticco, M AU - Mrakic-Sposta, S AU - Ferrucci, R AU - Zago, S AU - Polezzi, D AU - Sartori, G PY - 2007/06/21/ UR - http://dx.doi.org/10.1093/cercor/bhm088 ER -