The Genomics of Speciation in <italic>Drosophila</italic>: Diversity, Divergence, and Introgression Estimated Using Low-Coverage Genome Sequencing Export

@article{citeulike:5043838, abstract = {<title>Author Summary</title> <p>The transformation of populations into distinct species depends on whether hybridization, recombination, and subsequent gene introgression can be suppressed between diverging species. We use partial genome sequences to reconstruct this evolutionary process in the <italic>Drosophila pseudoobscura</italic> species subgroup, which includes the hybridizing species pair <italic>D. pseudoobscura pseudoobscura</italic> and <italic>D. persimilis</italic>. Recent models suggest that chromosomal inversions can facilitate the persistence of hybridizing species because of their effects on recombination, whereby inverted regions would exhibit higher nucleotide divergence than non-inverted regions. Indeed, <italic>D. pseudoobscura-D. persimilis</italic> nucleotide divergence outside these inverted regions is lower than within or near inversions, resembling <italic>D. ps. pseudoobscura</italic> levels of within-species nucleotide diversity. We also observe that recombination suppression in F₁ hybrids extends greater than 2 Mbp outside the inversion breakpoints. Furthermore, when genomic sequence of <italic>D. persimilis</italic> is compared to two sister subspecies—the hybridizing subspecies, <italic>D. ps. pseudoobscura</italic>, and a non-hybridizing control subspecies, <italic>D. ps. bogotana</italic>—autosomal divergence is lower in the former, demonstrating recent gene exchange. These lines of evidence support a speciation model in which the two hybridizing species persist despite the presence of recent genic introgression in collinear regions of the genome because of the reduced recombinational effects of the inversions that distinguish them.</p>}, author = {Kulathinal, Rob J. and Stevison, Laurie S. and Noor, Mohamed A.}, citeulike-article-id = {5043838}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000550}, doi = {10.1371/journal.pgen.1000550}, journal = {PLoS Genet}, keywords = {drosophila, evolution, genomics, phylogenetics, rearrangements, sequencing}, month = {July}, number = {7}, pages = {e1000550+}, posted-at = {2009-07-03 06:51:01}, priority = {2}, publisher = {Public Library of Science}, title = {The Genomics of Speciation in <italic>Drosophila</italic>: Diversity, Divergence, and Introgression Estimated Using Low-Coverage Genome Sequencing}, url = {http://dx.doi.org/10.1371/journal.pgen.1000550}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5043838 L3 - citeulike-article-id:5043838 N2 - <title>Author Summary</title> <p>The transformation of populations into distinct species depends on whether hybridization, recombination, and subsequent gene introgression can be suppressed between diverging species. We use partial genome sequences to reconstruct this evolutionary process in the <italic>Drosophila pseudoobscura</italic> species subgroup, which includes the hybridizing species pair <italic>D. pseudoobscura pseudoobscura</italic> and <italic>D. persimilis</italic>. Recent models suggest that chromosomal inversions can facilitate the persistence of hybridizing species because of their effects on recombination, whereby inverted regions would exhibit higher nucleotide divergence than non-inverted regions. Indeed, <italic>D. pseudoobscura-D. persimilis</italic> nucleotide divergence outside these inverted regions is lower than within or near inversions, resembling <italic>D. ps. pseudoobscura</italic> levels of within-species nucleotide diversity. We also observe that recombination suppression in F₁ hybrids extends greater than 2 Mbp outside the inversion breakpoints. Furthermore, when genomic sequence of <italic>D. persimilis</italic> is compared to two sister subspecies—the hybridizing subspecies, <italic>D. ps. pseudoobscura</italic>, and a non-hybridizing control subspecies, <italic>D. ps. bogotana</italic>—autosomal divergence is lower in the former, demonstrating recent gene exchange. These lines of evidence support a speciation model in which the two hybridizing species persist despite the presence of recent genic introgression in collinear regions of the genome because of the reduced recombinational effects of the inversions that distinguish them.</p> IS - 7 JF - PLoS Genet TI - The Genomics of Speciation in <italic>Drosophila</italic>: Diversity, Divergence, and Introgression Estimated Using Low-Coverage Genome Sequencing PB - Public Library of Science VL - 5 SP - e1000550 KW - drosophila KW - evolution KW - genomics KW - phylogenetics KW - rearrangements KW - sequencing AU - Kulathinal, Rob AU - Stevison, Laurie AU - Noor, Mohamed PY - 2009/07/03/ UR - http://dx.doi.org/10.1371/journal.pgen.1000550 ER -