Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold Export

@article{citeulike:6056896, abstract = {A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein–protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein–protein interaction by representatives of the MCR derived scaffold are presented.}, author = {Antuch, Walfrido and Menon, Sanjay and Chen, Quin-Zene and Lu, Yingchun and Sakamuri, Sukumar and Beck, Barbara and Schauer-Vuka\v{s}inovi\'{c}, Vesna and Agarwal, Seema and Hess, Sibylle and D\"{o}mling, Alexander}, citeulike-article-id = {6056896}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bmcl.2005.11.102}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0960894X05015416}, day = {15}, doi = {10.1016/j.bmcl.2005.11.102}, issn = {0960894X}, journal = {Bioorganic \& Medicinal Chemistry Letters}, keywords = {inibitori, lox-1}, month = {March}, number = {6}, pages = {1740--1743}, posted-at = {2009-11-02 16:52:28}, priority = {2}, title = {Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold}, url = {http://dx.doi.org/10.1016/j.bmcl.2005.11.102}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:6056896 L3 - citeulike-article-id:6056896 N2 - A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein–protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein–protein interaction by representatives of the MCR derived scaffold are presented. IS - 6 JF - Bioorganic & Medicinal Chemistry Letters SN - 0960894X EP - 1743 TI - Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold VL - 16 SP - 1740 KW - inibitori KW - lox-1 AU - Antuch, Walfrido AU - Menon, Sanjay AU - Chen, Quin-Zene AU - Lu, Yingchun AU - Sakamuri, Sukumar AU - Beck, Barbara AU - Schauer-Vukašinović, Vesna AU - Agarwal, Seema AU - Hess, Sibylle AU - Dömling, Alexander PY - 2006/03/15/ UR - http://dx.doi.org/10.1016/j.bmcl.2005.11.102 ER -