Antioxidant defence during cardiopulmonary bypass surgery. Export

@article{citeulike:5950296, abstract = {OBJECTIVE: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. METHODS: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. RESULTS: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30\%, respectively), returning to baseline values 24 h after surgery. The total antioxidant capacity has a maximum increase of 60\%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. CONCLUSION: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage.}, author = {Luyten, Chris R. and van Overveld, Frans J. and De Backer, Lieve A. and Sadowska, Anna M. and Rodrigus, Inez E. and De Hert, Stefan G. and De Backer, Wilfried A.}, citeulike-article-id = {5950296}, citeulike-linkout-0 = {http://www.biomedexperts.com/Abstract.bme/15784359}, citeulike-linkout-1 = {http://dx.doi.org/10.1016/j.ejcts.2004.12.013}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15784359}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15784359}, doi = {10.1016/j.ejcts.2004.12.013}, issn = {1010-7940}, journal = {European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery}, keywords = {antioxidant\_capacity, antioxidants, cardiac\_surgery, coronary\_artery\_bypass, glutathione\_peroxidase, oxidation\_products}, month = {April}, number = {4}, pages = {611--616}, posted-at = {2009-10-16 11:07:23}, priority = {0}, title = {Antioxidant defence during cardiopulmonary bypass surgery.}, url = {http://dx.doi.org/10.1016/j.ejcts.2004.12.013}, volume = {27}, year = {2005} }

TY - JOUR ID - citeulike:5950296 L3 - citeulike-article-id:5950296 N2 - OBJECTIVE: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. METHODS: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. RESULTS: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24 h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. CONCLUSION: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage. IS - 4 JF - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery SN - 1010-7940 EP - 616 TI - Antioxidant defence during cardiopulmonary bypass surgery. VL - 27 SP - 611 KW - antioxidant_capacity KW - antioxidants KW - cardiac_surgery KW - coronary_artery_bypass KW - glutathione_peroxidase KW - oxidation_products AU - Luyten, Chris AU - van Overveld, Frans AU - De Backer, Lieve AU - Sadowska, Anna AU - Rodrigus, Inez AU - De Hert, Stefan AU - De Backer, Wilfried PY - 2005/04// UR - http://dx.doi.org/10.1016/j.ejcts.2004.12.013 ER -