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pablocarb's engineering [8 articles]

Recent papers added to pablocarb's library classified by the tag engineering. You can also see everyone's engineering.

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	Enzyme design by chemical modification of protein scaffolds. Current opinion in chemical biology, Vol. 5, No. 6. (December 2001), pp. 696-704. by C. M. Tann, D. Qi, M. D. Distefano posted to synthetic_methods scaffold enzyme engineering biocatalysis by pablocarb on 2009-09-15 18:34:38 Abstract Copy My Attachments My Copy Abstract Covalent modification methods allow an almost unlimited range of functionality to be introduced into proteins. In concert with genetic techniques, chemical strategies have had significant impact in the field of enzyme design. Major recent developments include introducing catalytic activity into inactive proteins, modifying the selectivity and/or reactivity of existing enzymes and designing novel enzyme-based biosensors. New chemical methods promise to further increase the range of functionality that can be incorporated into proteins. These results suggest that semi-synthetic methods will play a ...
	Synthetic biology: new engineering rules for an emerging discipline. Molecular systems biology, Vol. 2 (16 May 2006), pp. msb4100073-E1-msb4100073-E14. by Ernesto Andrianantoandro, Subhayu Basu, David K. Karig, Ron Weiss posted to synthetic_biology enzyme engineering by pablocarb on 2009-08-26 14:44:36 along with 20 people jthorniley quantumbiology abhishek_tiwari sjayanthi druvus gvillar jec105 ClaireFB lenov Synthetic_Biology_Literature sharatjv johncumbers mmt margaritis jrbanga sujaikumar jbchang nicholasflann kevinchannon grahamc Abstract Copy My Attachments My Copy Abstract Synthetic biologists engineer complex artificial biological systems to investigate natural biological phenomena and for a variety of applications. We outline the basic features of synthetic biology as a new engineering discipline, covering examples from the latest literature and reflecting on the features that make it unique among all other existing engineering fields. We discuss methods for designing and constructing engineered cells with novel functions in a framework of an abstract hierarchy of biological devices, modules, cells, and multicellular systems. The classical ...
	Designed divergent evolution of enzyme function Nature, Vol. 440, No. 7087. (20 April 2006), pp. 1078-1082. by Yasuo Yoshikuni, Thomas E. Ferrin, Jay D. Keasling posted to function evolution enzyme engineering by pablocarb on 2009-08-26 13:29:26 along with 5 people and 2 groups ygygod lingchong marcius tny dbikard BioinfoCIPF SGU-CIPF Copy My Attachments My Copy
	How does an enzyme evolved in vitro compare to naturally occurring homologs possessing the targeted function? Tyrosine aminotransferase from aspartate aminotransferase. Journal of molecular biology, Vol. 327, No. 3. (28 March 2003), pp. 593-608. by S. C. Rothman, J. F. Kirsch posted to protein promiscuity evolution enzyme engineering by pablocarb on 2009-07-22 10:34:23 Abstract Copy My Attachments My Copy Abstract Aspartate aminotransferase (AATase) and tyrosine aminotransferase (TATase) are Escherichia coli paralogs that share 43% sequence identity. A plausible model posits that TATase arose from a duplication of an ancestral AATase-like enzyme. Directed evolution of AATase to an enzyme having TATase activity was undertaken in order to compare the evolved AATase variants with homologous TATases. Eight rounds of DNA shuffling and in vivo selection followed by a backcross with WT AATase produced enzymes that exhibited 100-270-fold increases in k(cat)/K(m)(Phe) and had as ...
	Biological Systems from an Engineer's Point of View PLoS Biol, Vol. 7, No. 1. (20 January 2009), e1000021. by Gregory T. Reeves, Scott E. Fraser posted to control engineering by pablocarb on 2009-02-02 23:02:59 along with 9 people GeeSharpMinor pansapiens nuin pawelszczesny tswayne dswan dullhunk aalibes druvus Abstract Copy My Attachments My Copy Abstract The robust design of complex systems, such as cruise control, requires a careful balance of several objectives. As biological systems are no different, an engineering approach to these systems proves useful. ...
	Synthetic biology: new engineering rules for an emerging discipline. Molecular systems biology [electronic resource]., Vol. 2 (2006), pp. 2006-0028. by Ernesto Andrianantoandro, Subhayu Basu, David Karig, Ron Weiss posted to synthetic_biology systems_biology engineering by pablocarb on 2009-01-17 17:02:00 Copy My Attachments My Copy
	Engineered gene circuits Nature, Vol. 420, No. 6912. (14 November 2002), pp. 224-230. by Jeff Hasty, David Mcmillen, J. Collins posted to systems_biology engineering by pablocarb on 2009-01-17 17:02:00 Notes Copy My Attachments My Copy Note (first note only) Feedback regulation and logic gates. Some examples and applications
	Systems biology - an engineering perspective Journal of Biotechnology (2007) posted to systems_biology engineering by pablocarb on 2009-01-17 17:02:00 Copy My Attachments My Copy

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