The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos. Export

@article{citeulike:5273032, abstract = {Hitherto no estimate has been available of the genetic polymorphisms of S-mephenytoin hydroxylation in the Saudi Arabian or any other Middle Eastern population. A total of 102 healthy Saudi Arabian volunteer subjects were tested simultaneously with mephenytoin and dextromethorphan. Two poor metabolizers of S-mephenytoin and two poor metabolizers of dextromethorphan were found. Also 55 healthy Filipino volunteer subjects were tested and 13 found to be poor metabolizers of S-mephenytoin, whilst none were found to be poor metabolizers of dextromethorphan. The Saudi Arabian population thus appears to resemble Europeans in the frequency of poor metabolizers of S-mephenytoin, but resembles Orientals in the frequency of poor metabolizers of dextromethorphan. The Filipino sample as expected resembles other Oriental samples in the frequencies of poor metabolizers of both drugs.}, author = {Evans, D. A. and Krahn, P. and Narayanan, N.}, citeulike-article-id = {5273032}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7663530}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7663530}, issn = {0960-314X}, journal = {Pharmacogenetics}, keywords = {cyp2b6, cyp2c19, philippines, saudi-arabia}, month = {April}, number = {2}, pages = {64--71}, posted-at = {2009-08-13 01:43:08}, priority = {2}, title = {The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7663530}, volume = {5}, year = {1995} }

TY - JOUR ID - citeulike:5273032 L3 - citeulike-article-id:5273032 N2 - Hitherto no estimate has been available of the genetic polymorphisms of S-mephenytoin hydroxylation in the Saudi Arabian or any other Middle Eastern population. A total of 102 healthy Saudi Arabian volunteer subjects were tested simultaneously with mephenytoin and dextromethorphan. Two poor metabolizers of S-mephenytoin and two poor metabolizers of dextromethorphan were found. Also 55 healthy Filipino volunteer subjects were tested and 13 found to be poor metabolizers of S-mephenytoin, whilst none were found to be poor metabolizers of dextromethorphan. The Saudi Arabian population thus appears to resemble Europeans in the frequency of poor metabolizers of S-mephenytoin, but resembles Orientals in the frequency of poor metabolizers of dextromethorphan. The Filipino sample as expected resembles other Oriental samples in the frequencies of poor metabolizers of both drugs. IS - 2 JF - Pharmacogenetics SN - 0960-314X EP - 71 TI - The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos. VL - 5 SP - 64 KW - cyp2b6 KW - cyp2c19 KW - philippines KW - saudi-arabia AU - Evans, DA AU - Krahn, P AU - Narayanan, N PY - 1995/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/7663530 ER -