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The origin of the genetic code: theories and their relationships, a review

by: Massimo D. Giulio
Biosystems, Vol. 80, No. 2. (May 2005), pp. 175-184, doi:10.1016/j.biosystems.2004.11.005  Key: citeulike:2151823

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Abstract

A review of the main theories proposed to explain the origin of the genetic code is presented. I analyze arguments and data in favour of different theories proposed to explain the origin of the organization of the genetic code. It is possible to suggest a mechanism that makes compatible the different theories of the origin of the code, even if these are based on a historical or physicochemical determinism and thus appear incompatible by definition. Finally, I discuss the question of why a given number of synonymous codons was attributed to the amino acids in the genetic code.


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