Cell cycle checkpoints and their inactivation in human cancer Export

@article{citeulike:5879458, abstract = {Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint.}, address = {European Institute of Oncology, Milan, Italy}, author = {Molinari, M.}, citeulike-article-id = {5879458}, citeulike-linkout-0 = {http://dx.doi.org/10.1046/j.1365-2184.2000.00191.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/119188437/ABSTRACT}, doi = {10.1046/j.1365-2184.2000.00191.x}, issn = {1365-2184}, journal = {Cell Proliferation}, keywords = {cell\_cycle\_checkpoints, cell\_cycle\_control, dna\_damage, human\_cancer}, number = {5}, pages = {261--274}, posted-at = {2009-10-02 20:01:41}, priority = {2}, title = {Cell cycle checkpoints and their inactivation in human cancer}, url = {http://dx.doi.org/10.1046/j.1365-2184.2000.00191.x}, volume = {33}, year = {2000} }

TY - JOUR ID - citeulike:5879458 L3 - citeulike-article-id:5879458 N2 - Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint. IS - 5 JF - Cell Proliferation SN - 1365-2184 AD - European Institute of Oncology, Milan, Italy EP - 274 TI - Cell cycle checkpoints and their inactivation in human cancer VL - 33 SP - 261 KW - cell_cycle_checkpoints KW - cell_cycle_control KW - dna_damage KW - human_cancer AU - Molinari, M PY - 2000/// UR - http://dx.doi.org/10.1046/j.1365-2184.2000.00191.x ER -