The bound states of amphipathic drugs in lipid bilayers: study of curcumin Export

@article{citeulike:2857940, abstract = {Drug-membrane interactions are well known but poorly understood. Here we describe dual measurements of membrane thickness change and membrane area change due to the binding of amphipathic drug curcumin. The combined results allowed us to analyze the binding states of a drug to lipid bilayers, one on the water-membrane interface and another in the hydrocarbon region of the bilayer. The transition between the two states is strongly affected by the elastic energy of membrane thinning (or equivalently area stretching) caused by interfacial binding. The data are well described by a two state model including this elastic energy. The binding of curcumin follows a common pattern of amphipathic peptides binding to membranes, suggesting that the binding states of curcumin are typical for amphipathic drugs. 10.1529/biophysj.108.133736}, author = {Sun, Yen and Lee, Chang-Chun and Hung, Wei-Chin and Chen, Fang-Yu and Lee, Ming-Tao and Huang, Huey W.}, citeulike-article-id = {2857940}, citeulike-linkout-0 = {http://dx.doi.org/10.1529/biophysj.108.133736}, citeulike-linkout-1 = {http://www.biophysj.org/cgi/content/abstract/95/5/2318}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18515370}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18515370}, day = {30}, doi = {10.1529/biophysj.108.133736}, journal = {Biophys. J.}, keywords = {amphiphile, membrane, sun08pdf, thinning}, month = {May}, pages = {biophysj.108.133736+}, posted-at = {2008-06-03 00:06:19}, priority = {2}, title = {The bound states of amphipathic drugs in lipid bilayers: study of curcumin}, url = {http://dx.doi.org/10.1529/biophysj.108.133736}, year = {2008} }

TY - JOUR ID - citeulike:2857940 L3 - citeulike-article-id:2857940 N2 - Drug-membrane interactions are well known but poorly understood. Here we describe dual measurements of membrane thickness change and membrane area change due to the binding of amphipathic drug curcumin. The combined results allowed us to analyze the binding states of a drug to lipid bilayers, one on the water-membrane interface and another in the hydrocarbon region of the bilayer. The transition between the two states is strongly affected by the elastic energy of membrane thinning (or equivalently area stretching) caused by interfacial binding. The data are well described by a two state model including this elastic energy. The binding of curcumin follows a common pattern of amphipathic peptides binding to membranes, suggesting that the binding states of curcumin are typical for amphipathic drugs. 10.1529/biophysj.108.133736 JF - Biophys. J. TI - The bound states of amphipathic drugs in lipid bilayers: study of curcumin SP - biophysj.108.133736 KW - amphiphile KW - membrane KW - sun08pdf KW - thinning AU - Sun, Yen AU - Lee, Chang-Chun AU - Hung, Wei-Chin AU - Chen, Fang-Yu AU - Lee, Ming-Tao AU - Huang, Huey PY - 2008/05/30/ UR - http://dx.doi.org/10.1529/biophysj.108.133736 ER -