Effects of Ether vs. Ester Linkage on Lipid Bilayer Structure and Water Permeability Export

@article{citeulike:4497077, abstract = {The structure and water permeability of bilayers composed of the ether linked lipid, dihexadecylphosphatidylcholine (DHPC), were studied and compared with the ester linked lipid, dipalmitoylphosphaditdylcholine (DPPC). Wide angle x-ray scattering on oriented bilayers in the fluid phase indicate that the area per lipid A is slightly larger for DHPC than for DPPC. Low angle x-ray scattering yields A = 65.1 \r{A} 2 for DHPC at 48 °C. LAXS data provide the bending modulus, K C  = 4.2x10 -13 erg, and the Hamaker parameter H = 7.2x10 -14 erg for the van der Waals attractive interaction between neighboring bilayers. For the low temperature phases with ordered hydrocarbon chains, we confirm the transition from a tilted L {\ss}' gel phase to an untilted, interdigitated L {\ss} I phase as the sample hydrates at 20 °C. Our measurement of water permeability, Pf = 0.022 cm/s at 48 °C for fluid phase DHPC is slightly smaller than that of DPPC, (Pf = 0.027 cm/s) at 50 °C, consistent with our triple slab theory of permeability.}, author = {Guler, Deren S. and Ghosh, Dipon D. and Pan, Jianjun and Matthai, John C. and Zeidel, Mark L. and Nagle, John F. and Tristram-Nagle, Stephanie}, citeulike-article-id = {4497077}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.chemphyslip.2009.04.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0009308409000772}, day = {04}, doi = {10.1016/j.chemphyslip.2009.04.003}, issn = {00093084}, journal = {Chemistry and Physics of Lipids}, keywords = {bilayer, effects, ester, ether, guler09pdf, lipid, permeability, warer}, month = {May}, posted-at = {2009-05-09 00:28:45}, priority = {2}, title = {Effects of Ether vs. Ester Linkage on Lipid Bilayer Structure and Water Permeability}, url = {http://dx.doi.org/10.1016/j.chemphyslip.2009.04.003}, year = {2009} }

TY - JOUR ID - citeulike:4497077 L3 - citeulike-article-id:4497077 N2 - The structure and water permeability of bilayers composed of the ether linked lipid, dihexadecylphosphatidylcholine (DHPC), were studied and compared with the ester linked lipid, dipalmitoylphosphaditdylcholine (DPPC). Wide angle x-ray scattering on oriented bilayers in the fluid phase indicate that the area per lipid A is slightly larger for DHPC than for DPPC. Low angle x-ray scattering yields A = 65.1 Å 2 for DHPC at 48 °C. LAXS data provide the bending modulus, K C  = 4.2x10 -13 erg, and the Hamaker parameter H = 7.2x10 -14 erg for the van der Waals attractive interaction between neighboring bilayers. For the low temperature phases with ordered hydrocarbon chains, we confirm the transition from a tilted L ß’ gel phase to an untilted, interdigitated L ß I phase as the sample hydrates at 20 °C. Our measurement of water permeability, Pf = 0.022 cm/s at 48 °C for fluid phase DHPC is slightly smaller than that of DPPC, (Pf = 0.027 cm/s) at 50 °C, consistent with our triple slab theory of permeability. JF - Chemistry and Physics of Lipids SN - 00093084 TI - Effects of Ether vs. Ester Linkage on Lipid Bilayer Structure and Water Permeability KW - bilayer KW - effects KW - ester KW - ether KW - guler09pdf KW - lipid KW - permeability KW - warer AU - Guler, Deren AU - Ghosh, Dipon AU - Pan, Jianjun AU - Matthai, John AU - Zeidel, Mark AU - Nagle, John AU - Tristram-Nagle, Stephanie PY - 2009/05/04/ UR - http://dx.doi.org/10.1016/j.chemphyslip.2009.04.003 ER -