Mitochondrial outer-membrane permeabilization and remodelling in apoptosis Export

@article{citeulike:5240911, abstract = {Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP.}, author = {Jourdain, Alexis and Martinou, Jean-Claude}, citeulike-article-id = {5240911}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biocel.2009.05.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1357272509001587}, day = {09}, doi = {10.1016/j.biocel.2009.05.001}, issn = {13572725}, journal = {The International Journal of Biochemistry \& Cell Biology}, keywords = {apoptosis, jourda09pdf, membrane, mitochondrial, outer, permeabilization, remodelling, review}, month = {October}, number = {10}, pages = {1884--1889}, posted-at = {2009-11-05 20:11:47}, priority = {2}, title = {Mitochondrial outer-membrane permeabilization and remodelling in apoptosis}, url = {http://dx.doi.org/10.1016/j.biocel.2009.05.001}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5240911 L3 - citeulike-article-id:5240911 N2 - Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP. IS - 10 JF - The International Journal of Biochemistry & Cell Biology SN - 13572725 EP - 1889 TI - Mitochondrial outer-membrane permeabilization and remodelling in apoptosis VL - 41 SP - 1884 KW - apoptosis KW - jourda09pdf KW - membrane KW - mitochondrial KW - outer KW - permeabilization KW - remodelling KW - review AU - Jourdain, Alexis AU - Martinou, Jean-Claude PY - 2009/10/09/ UR - http://dx.doi.org/10.1016/j.biocel.2009.05.001 ER -