Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams Export

@article{citeulike:5629089, abstract = {The biophysical underpinning of the lipid-raft concept in cellular membranes is the liquid-ordered phase that is induced by moderately high concentrations of cholesterol. Although the crucial feature is the coexistence of phase-separated fluid domains, direct evidence for this in mixtures of cholesterol with a single lipid is extremely sparse. More extensive evidence comes from ternary mixtures of a high chain-melting lipid and a low chain-melting lipid with cholesterol, including those containing sphingomyelin that are taken to be a raft paradigm. There is, however, not complete agreement between the various phase diagrams and their interpretation. In this review, the different ternary phase diagrams of cholesterol-containing systems are presented in a uniform way, using simple x , y -coordinates to increase accessibility for the non-specialist. It is then possible to appreciate the common features and examine critically the discrepancies and hence what direct biophysical evidence there is that supports the raft concept.}, author = {Marsh, Derek}, citeulike-article-id = {5629089}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbamem.2009.08.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0005273609002855}, day = {21}, doi = {10.1016/j.bbamem.2009.08.004}, issn = {00052736}, journal = {Biochimica et Biophysica Acta (BBA) - Biomembranes}, keywords = {cholesterol, diagrams, marsh09pdf, phase, ternary}, month = {October}, number = {10}, pages = {2114--2123}, posted-at = {2009-08-25 01:53:58}, priority = {2}, title = {Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams}, url = {http://dx.doi.org/10.1016/j.bbamem.2009.08.004}, volume = {1788}, year = {2009} }

TY - JOUR ID - citeulike:5629089 L3 - citeulike-article-id:5629089 N2 - The biophysical underpinning of the lipid-raft concept in cellular membranes is the liquid-ordered phase that is induced by moderately high concentrations of cholesterol. Although the crucial feature is the coexistence of phase-separated fluid domains, direct evidence for this in mixtures of cholesterol with a single lipid is extremely sparse. More extensive evidence comes from ternary mixtures of a high chain-melting lipid and a low chain-melting lipid with cholesterol, including those containing sphingomyelin that are taken to be a raft paradigm. There is, however, not complete agreement between the various phase diagrams and their interpretation. In this review, the different ternary phase diagrams of cholesterol-containing systems are presented in a uniform way, using simple x , y -coordinates to increase accessibility for the non-specialist. It is then possible to appreciate the common features and examine critically the discrepancies and hence what direct biophysical evidence there is that supports the raft concept. IS - 10 JF - Biochimica et Biophysica Acta (BBA) - Biomembranes SN - 00052736 EP - 2123 TI - Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams VL - 1788 SP - 2114 KW - cholesterol KW - diagrams KW - marsh09pdf KW - phase KW - ternary AU - Marsh, Derek PY - 2009/10/21/ UR - http://dx.doi.org/10.1016/j.bbamem.2009.08.004 ER -