Protein interactions with surfaces: Computational approaches and repellency

Study of protein adsorption to solid surfaces continues to be substantial because of its role in cellular responses to biomaterials, interest in molecular aspects such as conformation and orientation, new methods for making protein repellent surfaces, and new application areas such as nanoparticles and microfluidics. This brief review is based only on very recent articles of particular interest to the authors, who each have worked in this area for some time. Simulations of protein interactions with surfaces and protein repellent surfaces are the only subtopics reviewed here. ⺠Simulation of protein interactions with surfaces and protein repellency reviewed. ⺠Corrected force fields for simulations using peptide adsorption data. ⺠Explicit versus implicit water in simulations. ⺠‘Pursuit of zero’ protein adsorption continues with new repellent materials. ⺠Zwitterionic surfaces adsorb ultralow amounts of protein even from undiluted plasma.