Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits Export

@article{citeulike:581076, abstract = {Drug models of mental illness are considered useful if they provoke its characteristic symptoms. In this respect, ketamine and tetrahydrocannabinol (cannabis) are coming under increasing scrutiny as models for schizophrenia. However, although both undoubtedly produce psychotic symptoms characteristic of the disorder, we argue here that, because schizophrenia is also accompanied by cognitive deficits, a full understanding of the impact of these drugs on cognition will be crucial in taking these models further. Memory deficits are pronounced in schizophrenia and we focus upon patterns of working and episodic memory impairment produced by ketamine and cannabis, identifying overlaps between drug and illness. We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia.}, author = {Fletcher, Paul C. and Honey, Garry D.}, citeulike-article-id = {581076}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tics.2006.02.008}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VH9-4JFHD2B-1/2/e935e630705a70930778221226e752b8}, doi = {10.1016/j.tics.2006.02.008}, journal = {Trends in Cognitive Sciences}, keywords = {cannabis, drugs, memory, psychiatry, schizophrenia}, month = {April}, number = {4}, pages = {167--174}, posted-at = {2006-04-10 13:59:15}, priority = {2}, title = {Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits}, url = {http://dx.doi.org/10.1016/j.tics.2006.02.008}, volume = {10}, year = {2006} }

TY - JOUR ID - citeulike:581076 L3 - citeulike-article-id:581076 N2 - Drug models of mental illness are considered useful if they provoke its characteristic symptoms. In this respect, ketamine and tetrahydrocannabinol (cannabis) are coming under increasing scrutiny as models for schizophrenia. However, although both undoubtedly produce psychotic symptoms characteristic of the disorder, we argue here that, because schizophrenia is also accompanied by cognitive deficits, a full understanding of the impact of these drugs on cognition will be crucial in taking these models further. Memory deficits are pronounced in schizophrenia and we focus upon patterns of working and episodic memory impairment produced by ketamine and cannabis, identifying overlaps between drug and illness. We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia. IS - 4 JF - Trends in Cognitive Sciences EP - 174 TI - Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits VL - 10 SP - 167 KW - cannabis KW - drugs KW - memory KW - psychiatry KW - schizophrenia AU - Fletcher, Paul AU - Honey, Garry PY - 2006/04// UR - http://dx.doi.org/10.1016/j.tics.2006.02.008 ER -