The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog Export

@article{citeulike:4108210, abstract = {Objective To evaluate and compare the cardiopulmonary effects of induction of anesthesia with isoflurane (Iso), ketamine-diazepam (KD), or propofol-diazepam (PD) in hypovolemic dogs.Study design  Prospective randomized cross-over trial.Animals  Six healthy intact, mixed breed, female dogs weighing 20.7 ± 4.2 kg and aged 22 ± 2 months.Methods  Dogs had 30 mL kg22121 of blood removed at a rate of 1.5 mL kg22121 minute22121 under isoflurane anesthesia. Following a 30-minute recovery period, anesthesia was reinduced. Dogs were assigned to one of three treatments: isoflurane via facemask using 0.5\% incremental increases in the delivered concentration every 30 seconds, 1.25 mg kg22121 ketamine and 0.0625 mg kg22121 diazepam intravenously (IV) with doses repeated every 30 seconds as required, and 2 mg kg22121 propofol and 0.2 mg kg22121 diazepam IV followed by 1 mg kg22121 propofol increments IV every 30 seconds as required. Following endotracheal intubation all dogs received 1.7\% end-tidal isoflurane in oxygen. Cardiopulmonary variables were recorded at baseline (before induction) and at 5 or 10 minute intervals following endotracheal intubation.Results  Induction time was longer in Iso (4.98 ± 0.47 minutes) compared to KD (3.10 ± 0.47 minutes) or PD (3.22 ± 0.45 minutes). To produce anesthesia, KD received 4.9 ± 2.3 mg kg22121 ketamine and 0.24 ± 0.1 mg kg22121 diazepam, while PD received 2.2 ± 0.4 mg kg22121 propofol and 0.2 mg kg22121 diazepam. End-tidal isoflurane concentration immediately following intubation was 1.7 ± 0.4\% in Iso. Arterial blood pressure and heart rate were significantly higher in KD and PD compared to Iso and in KD compared to PD. Arterial carbon dioxide partial pressure was significantly higher in PD compared to KD and Iso immediately after induction.Conclusions and clinical relevance  In hypovolemic dogs, KD or PD, as used in this study to induce anesthesia, resulted in less hemodynamic depression compared to isoflurane.}, address = {Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada}, author = {Fayyaz, Sima and Kerr, Carolyn L. and Dyson, Doris H. and Mirakhur, Kuldip K.}, citeulike-article-id = {4108210}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1467-2995.2008.00437.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122198509/ABSTRACT}, doi = {10.1111/j.1467-2995.2008.00437.x}, journal = {Veterinary Anaesthesia and Analgesia}, keywords = {analgesia, anesthesia, critical}, number = {2}, pages = {110--123}, posted-at = {2009-02-26 19:40:52}, priority = {2}, title = {The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog}, url = {http://dx.doi.org/10.1111/j.1467-2995.2008.00437.x}, volume = {36}, year = {2009} }

TY - JOUR ID - citeulike:4108210 L3 - citeulike-article-id:4108210 N2 - Objective To evaluate and compare the cardiopulmonary effects of induction of anesthesia with isoflurane (Iso), ketamine-diazepam (KD), or propofol-diazepam (PD) in hypovolemic dogs.Study design  Prospective randomized cross-over trial.Animals  Six healthy intact, mixed breed, female dogs weighing 20.7 ± 4.2 kg and aged 22 ± 2 months.Methods  Dogs had 30 mL kg22121 of blood removed at a rate of 1.5 mL kg22121 minute22121 under isoflurane anesthesia. Following a 30-minute recovery period, anesthesia was reinduced. Dogs were assigned to one of three treatments: isoflurane via facemask using 0.5% incremental increases in the delivered concentration every 30 seconds, 1.25 mg kg22121 ketamine and 0.0625 mg kg22121 diazepam intravenously (IV) with doses repeated every 30 seconds as required, and 2 mg kg22121 propofol and 0.2 mg kg22121 diazepam IV followed by 1 mg kg22121 propofol increments IV every 30 seconds as required. Following endotracheal intubation all dogs received 1.7% end-tidal isoflurane in oxygen. Cardiopulmonary variables were recorded at baseline (before induction) and at 5 or 10 minute intervals following endotracheal intubation.Results  Induction time was longer in Iso (4.98 ± 0.47 minutes) compared to KD (3.10 ± 0.47 minutes) or PD (3.22 ± 0.45 minutes). To produce anesthesia, KD received 4.9 ± 2.3 mg kg22121 ketamine and 0.24 ± 0.1 mg kg22121 diazepam, while PD received 2.2 ± 0.4 mg kg22121 propofol and 0.2 mg kg22121 diazepam. End-tidal isoflurane concentration immediately following intubation was 1.7 ± 0.4% in Iso. Arterial blood pressure and heart rate were significantly higher in KD and PD compared to Iso and in KD compared to PD. Arterial carbon dioxide partial pressure was significantly higher in PD compared to KD and Iso immediately after induction.Conclusions and clinical relevance  In hypovolemic dogs, KD or PD, as used in this study to induce anesthesia, resulted in less hemodynamic depression compared to isoflurane. IS - 2 JF - Veterinary Anaesthesia and Analgesia AD - Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada EP - 123 TI - The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog VL - 36 SP - 110 KW - analgesia KW - anesthesia KW - critical AU - Fayyaz, Sima AU - Kerr, Carolyn AU - Dyson, Doris AU - Mirakhur, Kuldip PY - 2009/// UR - http://dx.doi.org/10.1111/j.1467-2995.2008.00437.x ER -