Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings Export

@article{citeulike:4452120, abstract = {An 18-month-old European shorthair cat was presented with a two week history of progressive decrease in consciousness, ambulatory tetraparesis, moderate ataxia and generalised decreased-to-absent postural reactions. Bilateral facial and nasal hypalgesia, absent menace response and anisocoria were found, and segmental spinal reflexes were normal. Neurological signs progressed to non-ambulatory tetraparesis, tremor and spinal hyperalgesia. Histopathological examination revealed a mild-to-moderate lymphoplasmacytic and histiocytic infiltration, predominantly in the dorsal spinal roots, cranial nerves and ganglia in association with marked demyelination and proliferation of Schwann cells. Neurons and axons were preserved. Lesions were multi-focal and varied in severity. A predominantly sensory polyganglioradiculoneuritis was diagnosed. This lesion has not been reported previously in cats. Rabies, herpesviruses, feline infectious peritonitis, feline immunodeficiency virus, Toxoplasma gondii and feline leukaemia virus were excluded as possible aetiologies. Infections by other viruses or an autoimmune disease are discussed.}, address = {Department of Clinical Research and Veterinary Public Health Vetsuisse Faculty, University of Berne, 3012 Berne, Switzerland}, author = {Henke, D. and Vandevelde, M. and Oevermann, A.}, citeulike-article-id = {4452120}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1748-5827.2009.00703.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/bsc/jsap/2009/00000050/00000005/art00008}, citeulike-linkout-2 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122261596/ABSTRACT}, doi = {10.1111/j.1748-5827.2009.00703.x}, issn = {1748-5827}, journal = {Journal of Small Animal Practice}, keywords = {feline, neuromuscular, neuropathy, peripheral}, number = {5}, pages = {246--250}, posted-at = {2009-09-02 18:17:05}, priority = {2}, publisher = {Blackwell Publishing}, title = {Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings}, url = {http://dx.doi.org/10.1111/j.1748-5827.2009.00703.x}, volume = {50}, year = {2009} }

TY - JOUR ID - citeulike:4452120 L3 - citeulike-article-id:4452120 N2 - An 18-month-old European shorthair cat was presented with a two week history of progressive decrease in consciousness, ambulatory tetraparesis, moderate ataxia and generalised decreased-to-absent postural reactions. Bilateral facial and nasal hypalgesia, absent menace response and anisocoria were found, and segmental spinal reflexes were normal. Neurological signs progressed to non-ambulatory tetraparesis, tremor and spinal hyperalgesia. Histopathological examination revealed a mild-to-moderate lymphoplasmacytic and histiocytic infiltration, predominantly in the dorsal spinal roots, cranial nerves and ganglia in association with marked demyelination and proliferation of Schwann cells. Neurons and axons were preserved. Lesions were multi-focal and varied in severity. A predominantly sensory polyganglioradiculoneuritis was diagnosed. This lesion has not been reported previously in cats. Rabies, herpesviruses, feline infectious peritonitis, feline immunodeficiency virus, Toxoplasma gondii and feline leukaemia virus were excluded as possible aetiologies. Infections by other viruses or an autoimmune disease are discussed. IS - 5 JF - Journal of Small Animal Practice SN - 1748-5827 AD - Department of Clinical Research and Veterinary Public Health Vetsuisse Faculty, University of Berne, 3012 Berne, Switzerland EP - 250 TI - Polyganglioradiculoneuritis in a young cat: clinical and histopathological findings PB - Blackwell Publishing VL - 50 SP - 246 KW - feline KW - neuromuscular KW - neuropathy KW - peripheral AU - Henke, D AU - Vandevelde, M AU - Oevermann, A PY - 2009/// UR - http://dx.doi.org/10.1111/j.1748-5827.2009.00703.x ER -