Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Export

@article{citeulike:1010965, abstract = {A scoring system, based on the immunophenotypic analysis of a panel of five membrane markers (CD5, CD22, CD23, FMC7, SmIg) was shown to be useful in the distinction between chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative diseases (non-CLL). We investigated whether the monoclonal antibody SN8 (CD79b) could improve our previous scoring system. Peripheral blood samples of 298 patients with CLL and 166 patients with non-CLL were analyzed by flow cytometry. Using the five standard markers, the accuracy of the scoring system was 91.8\%, using a cutoff of 4 points or higher, to distinguish CLL from non-CLL. This was increased to 96.6\% if SN8 was added and a cutoff of 4 points or higher was also used. A similar accuracy, 96.8\%, was observed if CD22 was excluded and a cutoff of 3 points or higher was used. Thus, the replacement of CD22 by SN8 in the original scoring system significantly increases its potential to discriminate between CLL and other B-cell lymphoproliferative diseases.}, address = {Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, England.}, author = {Moreau, E. J. and Matutes, E. and A'Hern, R. P. and Morilla, A. M. and Morilla, R. M. and Owusu-Ankomah, K. A. and Seon, B. K. and Catovsky, D.}, citeulike-article-id = {1010965}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9322589}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9322589}, issn = {0002-9173}, journal = {Am J Clin Pathol}, keywords = {cll, hematopathology}, month = {October}, number = {4}, pages = {378--382}, posted-at = {2006-12-24 00:00:44}, priority = {2}, title = {Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b).}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9322589}, volume = {108}, year = {1997} }

TY - JOUR ID - citeulike:1010965 L3 - citeulike-article-id:1010965 N2 - A scoring system, based on the immunophenotypic analysis of a panel of five membrane markers (CD5, CD22, CD23, FMC7, SmIg) was shown to be useful in the distinction between chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative diseases (non-CLL). We investigated whether the monoclonal antibody SN8 (CD79b) could improve our previous scoring system. Peripheral blood samples of 298 patients with CLL and 166 patients with non-CLL were analyzed by flow cytometry. Using the five standard markers, the accuracy of the scoring system was 91.8%, using a cutoff of 4 points or higher, to distinguish CLL from non-CLL. This was increased to 96.6% if SN8 was added and a cutoff of 4 points or higher was also used. A similar accuracy, 96.8%, was observed if CD22 was excluded and a cutoff of 3 points or higher was used. Thus, the replacement of CD22 by SN8 in the original scoring system significantly increases its potential to discriminate between CLL and other B-cell lymphoproliferative diseases. IS - 4 JF - Am J Clin Pathol SN - 0002-9173 AD - Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, England. EP - 382 TI - Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). VL - 108 SP - 378 KW - cll KW - hematopathology AU - Moreau, EJ AU - Matutes, E AU - A'Hern, RP AU - Morilla, AM AU - Morilla, RM AU - Owusu-Ankomah, KA AU - Seon, BK AU - Catovsky, D PY - 1997/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/9322589 ER -