A cytokine-mediated link between innate immunity, inflammation, and cancer. Export

@article{citeulike:3168376, abstract = {It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.}, address = {Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Republic of China.}, author = {Lin, Wan-Wan W. and Karin, Michael}, citeulike-article-id = {3168376}, citeulike-linkout-0 = {http://dx.doi.org/10.1172/JCI31537}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17476347}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17476347}, doi = {10.1172/JCI31537}, issn = {0021-9738}, journal = {The Journal of clinical investigation}, keywords = {pathophys}, month = {May}, number = {5}, pages = {1175--1183}, posted-at = {2008-08-28 01:56:44}, priority = {2}, title = {A cytokine-mediated link between innate immunity, inflammation, and cancer.}, url = {http://dx.doi.org/10.1172/JCI31537}, volume = {117}, year = {2007} }

TY - JOUR ID - citeulike:3168376 L3 - citeulike-article-id:3168376 N2 - It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression. IS - 5 JF - The Journal of clinical investigation SN - 0021-9738 AD - Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Republic of China. EP - 1183 TI - A cytokine-mediated link between innate immunity, inflammation, and cancer. VL - 117 SP - 1175 KW - pathophys AU - Lin, Wan-Wan AU - Karin, Michael PY - 2007/05// UR - http://dx.doi.org/10.1172/JCI31537 ER -