Alternative splicing of conserved exons is frequently species-specific in human and mouse. Export

@article{citeulike:399604, abstract = {In this article, we provide evidence that a frequent source of diversity between mammalian transcripts occurs as a consequence of species-specific alternative splicing (AS) of conserved exons. Using a highly predictive computational method, we estimate that >11\% of human and mouse cassette alternative exons undergo skipping in one species but constitutively splicing in the other. These species-specific AS events are predicted to modify conserved domains in proteins more frequently than other classes of AS events. The results thus provide evidence that species-specific AS of conserved exons constitutes an additional potential source of complexity and species-specific differences between mammals.}, address = {CH Best Institute, University of Toronto, 112 College Street, Toronto, Ontario, Canada M5G 1L6.}, author = {Pan, Q. and Bakowski, M. A. and Morris, Q. and Zhang, W. and Frey, B. J. and Hughes, T. R. and Blencowe, B. J.}, citeulike-article-id = {399604}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2004.12.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S016895250400321X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15661351}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15661351}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6TCY-4F29SP7-1/2/4d97a93dda3e86a03be72e2ee9fbc056}, doi = {10.1016/j.tig.2004.12.004}, issn = {0168-9525}, journal = {Trends Genet}, keywords = {alternative-splicing, species-specific}, month = {February}, number = {2}, pages = {73--77}, posted-at = {2009-02-04 03:17:37}, priority = {2}, title = {Alternative splicing of conserved exons is frequently species-specific in human and mouse.}, url = {http://dx.doi.org/10.1016/j.tig.2004.12.004}, volume = {21}, year = {2005} }

TY - JOUR ID - citeulike:399604 L3 - citeulike-article-id:399604 N2 - In this article, we provide evidence that a frequent source of diversity between mammalian transcripts occurs as a consequence of species-specific alternative splicing (AS) of conserved exons. Using a highly predictive computational method, we estimate that >11% of human and mouse cassette alternative exons undergo skipping in one species but constitutively splicing in the other. These species-specific AS events are predicted to modify conserved domains in proteins more frequently than other classes of AS events. The results thus provide evidence that species-specific AS of conserved exons constitutes an additional potential source of complexity and species-specific differences between mammals. IS - 2 JF - Trends Genet SN - 0168-9525 AD - CH Best Institute, University of Toronto, 112 College Street, Toronto, Ontario, Canada M5G 1L6. EP - 77 TI - Alternative splicing of conserved exons is frequently species-specific in human and mouse. VL - 21 SP - 73 KW - alternative-splicing KW - species-specific AU - Pan, Q AU - Bakowski, MA AU - Morris, Q AU - Zhang, W AU - Frey, BJ AU - Hughes, TR AU - Blencowe, BJ PY - 2005/02// UR - http://dx.doi.org/10.1016/j.tig.2004.12.004 ER -