Diversity and evolution of MicroRNA gene clusters. Export

@article{citeulike:4195106, abstract = {microRNA (miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a chromosome. Although a large number of miRNA clusters have been uncovered in animal and plant genomes, the functional consequences of this arrangement are still poorly understood. Located in a polycistron, the coexpressed miRNA clusters are pivotal in coordinately regulating multiple processes, including embryonic development, cell cycles and cell differentiation. In this review, based on recent progress, we discuss the genomic diversity of miRNA gene clusters, the coordination of expression and function of the clustered miRNAs, and the evolutionarily adaptive processes with gain and loss of the clustering miRNA genes mediated by duplication and transposition events.}, author = {Zhang, Y. and Zhang, R. and Su, B.}, citeulike-article-id = {4195106}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s11427-009-0032-5}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19294351}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19294351}, citeulike-linkout-3 = {http://www.springerlink.com/content/3n550w50x2377q55}, doi = {10.1007/s11427-009-0032-5}, issn = {1006-9305}, journal = {Science in China. Series C, Life sciences / Chinese Academy of Sciences}, keywords = {cluster, evolution, microrna}, month = {March}, number = {3}, pages = {261--266}, posted-at = {2009-03-24 06:41:44}, priority = {2}, title = {Diversity and evolution of MicroRNA gene clusters.}, url = {http://dx.doi.org/10.1007/s11427-009-0032-5}, volume = {52}, year = {2009} }

TY - JOUR ID - citeulike:4195106 L3 - citeulike-article-id:4195106 N2 - microRNA (miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a chromosome. Although a large number of miRNA clusters have been uncovered in animal and plant genomes, the functional consequences of this arrangement are still poorly understood. Located in a polycistron, the coexpressed miRNA clusters are pivotal in coordinately regulating multiple processes, including embryonic development, cell cycles and cell differentiation. In this review, based on recent progress, we discuss the genomic diversity of miRNA gene clusters, the coordination of expression and function of the clustered miRNAs, and the evolutionarily adaptive processes with gain and loss of the clustering miRNA genes mediated by duplication and transposition events. IS - 3 JF - Science in China. Series C, Life sciences / Chinese Academy of Sciences SN - 1006-9305 EP - 266 TI - Diversity and evolution of MicroRNA gene clusters. VL - 52 SP - 261 KW - cluster KW - evolution KW - microrna AU - Zhang, Y AU - Zhang, R AU - Su, B PY - 2009/03// UR - http://dx.doi.org/10.1007/s11427-009-0032-5 ER -