Genome-wide association study identifies eight loci associated with blood pressure. Export

@article{citeulike:4509172, abstract = {Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N </= 71,225 European ancestry, N </= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.}, author = {Newton-Cheh, Christopher and Johnson, Toby and Gateva, Vesela and Tobin, Martin D. D. and Bochud, Murielle and Coin, Lachlan and Najjar, Samer S. S. and Jing and Heath, Simon C. C. and Eyheramendy, Susana and Papadakis, Konstantinos and Voight, Benjamin F. F. and Scott, Laura J. J. and Zhang, Feng and Farrall, Martin and Tanaka, Toshiko and Wallace, Chris and Chambers, John C. C. and Khaw, Kay-Tee T. and Nilsson, Peter and van der Harst, Pim and Polidoro, Silvia and Grobbee, Diederick E. E. and Charlotte and Bots, Michiel L. L. and Wain, Louise V. V. and Elliott, Katherine S. S. and Teumer, Alexander and Luan, Jian'an and Lucas, Gavin and Kuusisto, Johanna and Burton, Paul R. R. and Hadley, David and Mcardle, Wendy L. L. and Brown, Morris and Dominiczak, Anna and Newhouse, Stephen J. J. and Samani, Nilesh J. J. and Webster, John and Zeggini, Eleftheria and Beckmann, Jacques S. S. and Bergmann, Sven and Lim, Noha and Song, Kijoung and Vollenweider, Peter and Waeber, Gerard and Waterworth, Dawn M. M. and Yuan, Xin and Groop, Leif and Orho-Melander, Marju and Allione, Alessandra and Di Gregorio, Alessandra and Guarrera, Simonetta and Panico, Salvatore and Ricceri, Fulvio and Romanazzi, Valeria and Sacerdote, Carlotta and Vineis, Paolo and Barroso, In\^{e}s and Sandhu, Manjinder S. S. and Luben, Robert N. N. and Crawford, Gabriel J. J. and Jousilahti, Pekka and Perola, Markus and Boehnke, Michael and Bonnycastle, Lori L. L. and Collins, Francis S. S. and Jackson, Anne U. U. and Mohlke, Karen L. L. and Stringham, Heather M. M. and Valle, Timo T. T. and Willer, Cristen J. J. and Bergman, Richard N. N. and Morken, Mario A. A. and D\"{o}ring, Angela and Gieger, Christian and Illig, Thomas and Meitinger, Thomas and Org, Elin and Pfeufer, Arne and Erich and Kathiresan, Sekar and Marrugat, Jaume and O'Donnell, Christopher J. J. and Schwartz, Stephen M. M. and Siscovick, David S. S. and Subirana, Isaac and Freimer, Nelson B. B. and Hartikainen, Anna-Liisa L. and Mccarthy, Mark I. I. and O'Reilly, Paul F. F. and Peltonen, Leena and Pouta, Anneli and de Jong, Paul E. E. and Snieder, Harold and van Gilst, Wiek H. H. and Clarke, Robert and Goel, Anuj and Hamsten, Anders and Peden, John F. F. and Seedorf, Udo and Syv\"{a}nen, Ann-Christine C. and Tognoni, Giovanni and Lakatta, Edward G. G. and Sanna, Serena and Scheet, Paul and Schlessinger, David and Scuteri, Angelo and D\"{o}rr, Marcus and Ernst, Florian and Felix, Stephan B. B. and Homuth, Georg and Lorbeer, Roberto and Reffelmann, Thorsten and Rettig, Rainer and V\"{o}lker, Uwe and Galan, Pilar and Gut, Ivo G. G. and Hercberg, Serge and Mark and Zelenika, Diana and Deloukas, Panos and Soranzo, Nicole and Williams, Frances M. M. and Zhai, Guangju and Salomaa, Veikko and Laakso, Markku and Elosua, Roberto and Forouhi, Nita G. G. and V\"{o}lzke, Henry and Uiterwaal, Cuno S. S. and van der Schouw, Yvonne T. T. and Numans, Mattijs E. E. and Matullo, Giuseppe and Navis, Gerjan and Berglund, G\"{o}ran and Bingham, Sheila A. A. and Kooner, Jaspal S. S. and Connell, John M. M. and Bandinelli, Stefania and Ferrucci, Luigi and Watkins, Hugh and Spector, Tim D. D. and Tuomilehto, Jaakko and Altshuler, David and Strachan, David P. P. and Laan, Maris and Meneton, Pierre and Wareham, Nicholas J. J. and Uda, Manuela and Jarvelin, Marjo-Riitta R. and Mooser, Vincent and Melander, Olle and Ruth and Elliott, Paul and Abecasis, Gon\c{c}alo R. R. and Caulfield, Mark and Munroe, Patricia B. B.}, citeulike-article-id = {4509172}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.361}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.361}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19430483}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19430483}, day = {10}, doi = {10.1038/ng.361}, issn = {1546-1718}, journal = {Nature genetics}, keywords = {blood-pressure, gwas}, month = {May}, posted-at = {2009-05-29 04:37:11}, priority = {2}, title = {Genome-wide association study identifies eight loci associated with blood pressure.}, url = {http://dx.doi.org/10.1038/ng.361}, year = {2009} }

TY - JOUR ID - citeulike:4509172 L3 - citeulike-article-id:4509172 N2 - Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N </= 71,225 European ancestry, N </= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. JF - Nature genetics SN - 1546-1718 TI - Genome-wide association study identifies eight loci associated with blood pressure. KW - blood-pressure KW - gwas AU - Newton-Cheh, Christopher AU - Johnson, Toby AU - Gateva, Vesela AU - Tobin, Martin AU - Bochud, Murielle AU - Coin, Lachlan AU - Najjar, Samer AU - Jing AU - Heath, Simon AU - Eyheramendy, Susana AU - Papadakis, Konstantinos AU - Voight, Benjamin AU - Scott, Laura AU - Zhang, Feng AU - Farrall, Martin AU - Tanaka, Toshiko AU - Wallace, Chris AU - Chambers, John AU - Khaw, Kay-Tee AU - Nilsson, Peter AU - van der Harst, Pim AU - Polidoro, Silvia AU - Grobbee, Diederick AU - Charlotte AU - Bots, Michiel AU - Wain, Louise AU - Elliott, Katherine AU - Teumer, Alexander AU - Luan, Jian'an AU - Lucas, Gavin AU - Kuusisto, Johanna AU - Burton, Paul AU - Hadley, David AU - Mcardle, Wendy AU - Brown, Morris AU - Dominiczak, Anna AU - Newhouse, Stephen AU - Samani, Nilesh AU - Webster, John AU - Zeggini, Eleftheria AU - Beckmann, Jacques AU - Bergmann, Sven AU - Lim, Noha AU - Song, Kijoung AU - Vollenweider, Peter AU - Waeber, Gerard AU - Waterworth, Dawn AU - Yuan, Xin AU - Groop, Leif AU - Orho-Melander, Marju AU - Allione, Alessandra AU - Di Gregorio, Alessandra AU - Guarrera, Simonetta AU - Panico, Salvatore AU - Ricceri, Fulvio AU - Romanazzi, Valeria AU - Sacerdote, Carlotta AU - Vineis, Paolo AU - Barroso, Inês AU - Sandhu, Manjinder AU - Luben, Robert AU - Crawford, Gabriel AU - Jousilahti, Pekka AU - Perola, Markus AU - Boehnke, Michael AU - Bonnycastle, Lori AU - Collins, Francis AU - Jackson, Anne AU - Mohlke, Karen AU - Stringham, Heather AU - Valle, Timo AU - Willer, Cristen AU - Bergman, Richard AU - Morken, Mario AU - Döring, Angela AU - Gieger, Christian AU - Illig, Thomas AU - Meitinger, Thomas AU - Org, Elin AU - Pfeufer, Arne AU - Erich AU - Kathiresan, Sekar AU - Marrugat, Jaume AU - O'Donnell, Christopher AU - Schwartz, Stephen AU - Siscovick, David AU - Subirana, Isaac AU - Freimer, Nelson AU - Hartikainen, Anna-Liisa AU - Mccarthy, Mark AU - O'Reilly, Paul AU - Peltonen, Leena AU - Pouta, Anneli AU - de Jong, Paul AU - Snieder, Harold AU - van Gilst, Wiek AU - Clarke, Robert AU - Goel, Anuj AU - Hamsten, Anders AU - Peden, John AU - Seedorf, Udo AU - Syvänen, Ann-Christine AU - Tognoni, Giovanni AU - Lakatta, Edward AU - Sanna, Serena AU - Scheet, Paul AU - Schlessinger, David AU - Scuteri, Angelo AU - Dörr, Marcus AU - Ernst, Florian AU - Felix, Stephan AU - Homuth, Georg AU - Lorbeer, Roberto AU - Reffelmann, Thorsten AU - Rettig, Rainer AU - Völker, Uwe AU - Galan, Pilar AU - Gut, Ivo AU - Hercberg, Serge AU - Mark AU - Zelenika, Diana AU - Deloukas, Panos AU - Soranzo, Nicole AU - Williams, Frances AU - Zhai, Guangju AU - Salomaa, Veikko AU - Laakso, Markku AU - Elosua, Roberto AU - Forouhi, Nita AU - Völzke, Henry AU - Uiterwaal, Cuno AU - van der Schouw, Yvonne AU - Numans, Mattijs AU - Matullo, Giuseppe AU - Navis, Gerjan AU - Berglund, Göran AU - Bingham, Sheila AU - Kooner, Jaspal AU - Connell, John AU - Bandinelli, Stefania AU - Ferrucci, Luigi AU - Watkins, Hugh AU - Spector, Tim AU - Tuomilehto, Jaakko AU - Altshuler, David AU - Strachan, David AU - Laan, Maris AU - Meneton, Pierre AU - Wareham, Nicholas AU - Uda, Manuela AU - Jarvelin, Marjo-Riitta AU - Mooser, Vincent AU - Melander, Olle AU - Ruth AU - Elliott, Paul AU - Abecasis, Gonçalo AU - Caulfield, Mark AU - Munroe, Patricia PY - 2009/05/10/ UR - http://dx.doi.org/10.1038/ng.361 ER -