Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. Export

@article{citeulike:1194376, abstract = {Activation of cAMP synthesis by intracellular Ca2+ is thought to be the main mode of cAMP generation in the brain. Accordingly, the Ca2+-activated adenylyl cyclases I and VIII are expressed prominently in forebrain neurons. The present study shows that the novel adenylyl cyclase type IX is inhibited by Ca2+ and that this effect is blocked selectively by inhibitors of calcineurin such as FK506 and cyclosporin A. Moreover, adenylyl cyclase IX is inhibited by the same range of intracellular free Ca2+ concentrations that stimulate adenylyl cyclase I. Adenylyl cyclase IX is expressed prominently in the forebrain. Substantial arrays of neurons positive for AC9 mRNA were found in the olfactory lobe, in limbic and neocortical areas, in the striatum, and in the cerebellar system. These data show that the initiation of the cAMP signal by adenylyl cyclase may be controlled by Ca2+/calcineurin and thus provide evidence for a novel mode of tuning the cAMP signal by protein phosphorylation/dephosphorylation cascades.}, address = {Medial Research Council Brain Metabolism Unit, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, United Kingdom.}, author = {Antoni, F. A. and Palkovits, M. and Simpson, J. and Smith, S. M. and Leitch, A. L. and Rosie, R. and Fink, G. and Paterson, J. M.}, citeulike-article-id = {1194376}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9822726}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9822726}, day = {1}, issn = {0270-6474}, journal = {J Neurosci}, keywords = {adenylatecyclase, calcineurin, camp}, month = {December}, number = {23}, pages = {9650--9661}, posted-at = {2007-03-29 08:53:29}, priority = {2}, title = {Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9822726}, volume = {18}, year = {1998} }

TY - JOUR ID - citeulike:1194376 L3 - citeulike-article-id:1194376 N2 - Activation of cAMP synthesis by intracellular Ca2+ is thought to be the main mode of cAMP generation in the brain. Accordingly, the Ca2+-activated adenylyl cyclases I and VIII are expressed prominently in forebrain neurons. The present study shows that the novel adenylyl cyclase type IX is inhibited by Ca2+ and that this effect is blocked selectively by inhibitors of calcineurin such as FK506 and cyclosporin A. Moreover, adenylyl cyclase IX is inhibited by the same range of intracellular free Ca2+ concentrations that stimulate adenylyl cyclase I. Adenylyl cyclase IX is expressed prominently in the forebrain. Substantial arrays of neurons positive for AC9 mRNA were found in the olfactory lobe, in limbic and neocortical areas, in the striatum, and in the cerebellar system. These data show that the initiation of the cAMP signal by adenylyl cyclase may be controlled by Ca2+/calcineurin and thus provide evidence for a novel mode of tuning the cAMP signal by protein phosphorylation/dephosphorylation cascades. IS - 23 JF - J Neurosci SN - 0270-6474 AD - Medial Research Council Brain Metabolism Unit, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, United Kingdom. EP - 9661 TI - Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. VL - 18 SP - 9650 KW - adenylatecyclase KW - calcineurin KW - camp AU - Antoni, FA AU - Palkovits, M AU - Simpson, J AU - Smith, SM AU - Leitch, AL AU - Rosie, R AU - Fink, G AU - Paterson, JM PY - 1998/12/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9822726 ER -