Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation Export

@article{citeulike:1267942, abstract = {Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, Ih, in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic Ih in hippocampal maturation. 10.1523/JNEUROSCI.4699-06.2007}, author = {Bender, Roland A. and Kirschstein, Timo and Kretz, Oliver and Brewster, Amy L. and Richichi, Cristina and Ruschenschmidt, Christiane and Shigemoto, Ryuichi and Beck, Heinz and Frotscher, Michael and Baram, Tallie Z.}, citeulike-article-id = {1267942}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.4699}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/27/17/4697}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17460082}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17460082}, day = {25}, doi = {10.1523/JNEUROSCI.4699}, journal = {J. Neurosci.}, keywords = {developpement, hcn, hcn1, plasticity}, month = {April}, number = {17}, pages = {4697--4706}, posted-at = {2007-04-30 14:25:23}, priority = {4}, title = {Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4699}, volume = {27}, year = {2007} }

TY - JOUR ID - citeulike:1267942 L3 - citeulike-article-id:1267942 N2 - Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, Ih, in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic Ih in hippocampal maturation. 10.1523/JNEUROSCI.4699-06.2007 IS - 17 JF - J. Neurosci. EP - 4706 TI - Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation VL - 27 SP - 4697 KW - developpement KW - hcn KW - hcn1 KW - plasticity AU - Bender, Roland AU - Kirschstein, Timo AU - Kretz, Oliver AU - Brewster, Amy AU - Richichi, Cristina AU - Ruschenschmidt, Christiane AU - Shigemoto, Ryuichi AU - Beck, Heinz AU - Frotscher, Michael AU - Baram, Tallie PY - 2007/04/25/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4699 ER -