Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

@article{citeulike:1443811, abstract = {Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.}, address = {Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA. tzingoun@cmpmail.ucsf.edu}, author = {Tzingounis, A. V. and Nicoll, R. A.}, citeulike-article-id = {1443811}, doi = {10.1016/j.neuron.2006.10.016}, issn = {0896-6273}, journal = {Neuron}, keywords = {arc, revue}, month = {November}, number = {3}, pages = {403--407}, posted-at = {2007-07-09 10:50:50}, priority = {2}, title = {Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.}, url = {http://dx.doi.org/10.1016/j.neuron.2006.10.016}, volume = {52}, year = {2006} }

TY - JOUR ID - citeulike:1443811 L3 - citeulike-article-id:1443811 N2 - Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker. IS - 3 JF - Neuron SN - 0896-6273 AD - Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA. tzingoun@cmpmail.ucsf.edu EP - 407 TI - Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. VL - 52 SP - 403 KW - arc KW - revue AU - Tzingounis, AV AU - Nicoll, RA PY - 2006/11/09/ UR - http://dx.doi.org/10.1016/j.neuron.2006.10.016 ER -