Localization of a Stable Neural Correlate of Associative Memory Export

@article{citeulike:1610369, abstract = {Do learning and retrieval of a memory activate the same neurons? Does the number of reactivated neurons correlate with memory strength? We developed a transgenic mouse that enables the long-lasting genetic tagging of c-fosactive neurons. We found neurons in the basolateral amygdala that are activated during Pavlovian fear conditioning and are reactivated during memory retrieval. The number of reactivated neurons correlated positively with the behavioral expression of the fear memory, indicating a stable neural correlate of associative memory. The ability to manipulate these neurons genetically should allow a more precise dissection of the molecular mechanisms of memory encoding within a distributed neuronal network. 10.1126/science.1143839}, author = {Reijmers, Leon G. and Perkins, Brian L. and Matsuo, Naoki and Mayford, Mark}, citeulike-article-id = {1610369}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1143839}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/317/5842/1230}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17761885}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17761885}, day = {31}, doi = {10.1126/science.1143839}, journal = {Science}, keywords = {c-fos, fearconditioning, ieg, memoire}, month = {August}, number = {5842}, pages = {1230--1233}, posted-at = {2007-08-31 12:46:29}, priority = {2}, title = {Localization of a Stable Neural Correlate of Associative Memory}, url = {http://dx.doi.org/10.1126/science.1143839}, volume = {317}, year = {2007} }

TY - JOUR ID - citeulike:1610369 L3 - citeulike-article-id:1610369 N2 - Do learning and retrieval of a memory activate the same neurons? Does the number of reactivated neurons correlate with memory strength? We developed a transgenic mouse that enables the long-lasting genetic tagging of c-fosactive neurons. We found neurons in the basolateral amygdala that are activated during Pavlovian fear conditioning and are reactivated during memory retrieval. The number of reactivated neurons correlated positively with the behavioral expression of the fear memory, indicating a stable neural correlate of associative memory. The ability to manipulate these neurons genetically should allow a more precise dissection of the molecular mechanisms of memory encoding within a distributed neuronal network. 10.1126/science.1143839 IS - 5842 JF - Science EP - 1233 TI - Localization of a Stable Neural Correlate of Associative Memory VL - 317 SP - 1230 KW - c-fos KW - fearconditioning KW - ieg KW - memoire AU - Reijmers, Leon AU - Perkins, Brian AU - Matsuo, Naoki AU - Mayford, Mark PY - 2007/08/31/ UR - http://dx.doi.org/10.1126/science.1143839 ER -