A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Export

@article{citeulike:1699817, abstract = {The induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus is associated with a rapid and robust transcription of the immediate early gene Zif268. We used a mutant mouse with a targeted disruption of Zif268 to ask whether this gene, which encodes a zinc finger transcription factor, is required for the maintenance of late LTP and for the expression of long-term memory. We show that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal. In both spatial and non-spatial learning tasks, short-term memory remained intact, whereas performance was impaired in tests requiring long-term memory. Thus, Zif268 is essential for the transition from short- to long-term synaptic plasticity and for the expression of long-term memories.}, address = {Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.}, author = {Jones, M. W. and Errington, M. L. and French, P. J. and Fine, A. and Bliss, T. V. and Garel, S. and Charnay, P. and Bozon, B. and Laroche, S. and Davis, S.}, citeulike-article-id = {1699817}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/85138}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11224546}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11224546}, doi = {10.1038/85138}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {ieg, ltp, memoire, zif268}, month = {March}, number = {3}, pages = {289--296}, posted-at = {2007-09-27 11:02:17}, priority = {2}, title = {A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories.}, url = {http://dx.doi.org/10.1038/85138}, volume = {4}, year = {2001} }

TY - JOUR ID - citeulike:1699817 L3 - citeulike-article-id:1699817 N2 - The induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus is associated with a rapid and robust transcription of the immediate early gene Zif268. We used a mutant mouse with a targeted disruption of Zif268 to ask whether this gene, which encodes a zinc finger transcription factor, is required for the maintenance of late LTP and for the expression of long-term memory. We show that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal. In both spatial and non-spatial learning tasks, short-term memory remained intact, whereas performance was impaired in tests requiring long-term memory. Thus, Zif268 is essential for the transition from short- to long-term synaptic plasticity and for the expression of long-term memories. IS - 3 JF - Nat Neurosci SN - 1097-6256 AD - Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. EP - 296 TI - A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. VL - 4 SP - 289 KW - ieg KW - ltp KW - memoire KW - zif268 AU - Jones, MW AU - Errington, ML AU - French, PJ AU - Fine, A AU - Bliss, TV AU - Garel, S AU - Charnay, P AU - Bozon, B AU - Laroche, S AU - Davis, S PY - 2001/03// UR - http://dx.doi.org/10.1038/85138 ER -