The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty Export

@article{citeulike:2296822, abstract = {Emerging evidence indicates that the amygdala and the hippocampus play an important role in the pathophysiology of major psychotic disorders. Consistent with this evidence, and with data indicating amygdala modulation of hippocampal activity, animal model investigations have shown that a disruption of amygdala activity induces neurochemical changes in the hippocampus that are similar to those detected in subjects with schizophrenia. With the present study, we used induction of the immediate early gene Fos, to test the hypothesis that the amygdala may affect neuronal activation of the hippocampus in response to different spatial environments (familiar, modified, and novel). Exploratory and anxiety related behaviors were also assessed. In vehicle-treated rats, exposure to a modified version of the familiar environment was associated with an increase of numerical densities of Fos-immunoreactive nuclei in sectors CA1 and CA2, while exposure to a completely novel environment was associated with an increase in sectors CA1, CA4, and DG, compared with the familiar environment. Pharmacological disruption of amygdala activity resulted in a failure to increase Fos induction in the hippocampus in response to these environments. Exploratory behavior in response to the different environments was not altered by manipulation of amygdala activity. These findings support the idea that the amygdala modulates spatial information processing in the hippocampus and may affect encoding of specific environmental features, while complex behavioral responses to environment may be the result of broader neural circuits. These findings also raise the possibility that amygdala abnormalities may contribute to impairments in cognitive information processing in subjects with major psychoses. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Department of Psychology, Boston University, Boston, Massachusetts; Laboratory for Translational Neuroscience, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts; Statistical Neuroimaging Laboratory, McLean Hospital, Belmont, Massachusetts}, author = {Sheth, Archana and Berretta, Sabina and Lange, Nicholas and Eichenbaum, Howard}, citeulike-article-id = {2296822}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/hipo.20380}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/116834128/ABSTRACT}, doi = {10.1002/hipo.20380}, journal = {Hippocampus}, keywords = {amygdala, c-fos, hippocampe, ieg, schizophrenie}, number = {2}, pages = {169--181}, posted-at = {2008-07-23 14:32:11}, priority = {2}, title = {The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty}, url = {http://dx.doi.org/10.1002/hipo.20380}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:2296822 L3 - citeulike-article-id:2296822 N2 - Emerging evidence indicates that the amygdala and the hippocampus play an important role in the pathophysiology of major psychotic disorders. Consistent with this evidence, and with data indicating amygdala modulation of hippocampal activity, animal model investigations have shown that a disruption of amygdala activity induces neurochemical changes in the hippocampus that are similar to those detected in subjects with schizophrenia. With the present study, we used induction of the immediate early gene Fos, to test the hypothesis that the amygdala may affect neuronal activation of the hippocampus in response to different spatial environments (familiar, modified, and novel). Exploratory and anxiety related behaviors were also assessed. In vehicle-treated rats, exposure to a modified version of the familiar environment was associated with an increase of numerical densities of Fos-immunoreactive nuclei in sectors CA1 and CA2, while exposure to a completely novel environment was associated with an increase in sectors CA1, CA4, and DG, compared with the familiar environment. Pharmacological disruption of amygdala activity resulted in a failure to increase Fos induction in the hippocampus in response to these environments. Exploratory behavior in response to the different environments was not altered by manipulation of amygdala activity. These findings support the idea that the amygdala modulates spatial information processing in the hippocampus and may affect encoding of specific environmental features, while complex behavioral responses to environment may be the result of broader neural circuits. These findings also raise the possibility that amygdala abnormalities may contribute to impairments in cognitive information processing in subjects with major psychoses. © 2007 Wiley-Liss, Inc. IS - 2 JF - Hippocampus AD - Department of Psychology, Boston University, Boston, Massachusetts; Laboratory for Translational Neuroscience, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts; Statistical Neuroimaging Laboratory, McLean Hospital, Belmont, Massachusetts EP - 181 TI - The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty VL - 18 SP - 169 KW - amygdala KW - c-fos KW - hippocampe KW - ieg KW - schizophrenie AU - Sheth, Archana AU - Berretta, Sabina AU - Lange, Nicholas AU - Eichenbaum, Howard PY - 2008/// UR - http://dx.doi.org/10.1002/hipo.20380 ER -