Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Export

@article{citeulike:337804, abstract = {Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.}, address = {Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.}, author = {Bissi\`{e}re, S. and Humeau, Y. and L\"{u}thi, A.}, citeulike-article-id = {337804}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn1058}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12740581}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12740581}, doi = {10.1038/nn1058}, issn = {1097-6256}, journal = {Nature neuroscience}, keywords = {amygdala, bla, dopamin, feed-forward, ltp}, month = {June}, number = {6}, pages = {587--592}, posted-at = {2009-07-21 10:25:51}, priority = {2}, title = {Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition.}, url = {http://dx.doi.org/10.1038/nn1058}, volume = {6}, year = {2003} }

TY - JOUR ID - citeulike:337804 L3 - citeulike-article-id:337804 N2 - Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala. IS - 6 JF - Nature neuroscience SN - 1097-6256 AD - Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. EP - 592 TI - Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. VL - 6 SP - 587 KW - amygdala KW - bla KW - dopamin KW - feed-forward KW - ltp AU - Bissière, S AU - Humeau, Y AU - Lüthi, A PY - 2003/06// UR - http://dx.doi.org/10.1038/nn1058 ER -