Interlaminar Differences of Intrinsic Properties of Pyramidal Neurons in the Auditory Cortex of Mice Export

@article{citeulike:3381319, abstract = {Cortical information processing depends crucially upon intrinsic neuronal properties modulating a given synaptic input, in addition to integration of excitatory and inhibitory inputs. These intrinsic mechanisms are poorly understood in sensory cortex areas. We therefore investigated neuronal properties in slices of the auditory cortex (AC) of normal hearing mice using whole-cell patch-clamp recordings of pyramidal neurons in layers II/III, IV, V, and VI in the current- and voltage clamp mode. A total of 234 pyramidal neurons were included in the analysis revealing distinct laminar differences. Regular spiking (RS) neurons in layer II/III have significantly lower resting membrane potential, higher threshold for action potential generation, and larger Kir and Ih amplitudes compared with layer V and VI RS neurons. These currents could improve temporal resolution in the upper layers of the AC. Additionally, the presence of a T-type Ca2+ current could be an important factor of RS neurons in these upper layers to amplify temporally closely correlated inputs. Compared with upper layers, lower layers (V and VI) exhibit a higher relative abundance of intrinsic bursting neurons. These neurons may provide layer-specific transfer functions for interlaminar, intercortical, and corticofugal information processing. 10.1093/cercor/bhn143}, author = {Huggenberger, Stefan and Vater, Marianne and Deisz, Rudolf A.}, citeulike-article-id = {3381319}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/cercor/bhn143}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18775844}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18775844}, doi = {10.1093/cercor/bhn143}, journal = {Cereb. Cortex}, keywords = {hcn, pyramidal}, month = {September}, pages = {bhn143+}, posted-at = {2008-10-07 08:51:02}, priority = {2}, title = {Interlaminar Differences of Intrinsic Properties of Pyramidal Neurons in the Auditory Cortex of Mice}, url = {http://dx.doi.org/10.1093/cercor/bhn143}, year = {2008} }

TY - JOUR ID - citeulike:3381319 L3 - citeulike-article-id:3381319 N2 - Cortical information processing depends crucially upon intrinsic neuronal properties modulating a given synaptic input, in addition to integration of excitatory and inhibitory inputs. These intrinsic mechanisms are poorly understood in sensory cortex areas. We therefore investigated neuronal properties in slices of the auditory cortex (AC) of normal hearing mice using whole-cell patch-clamp recordings of pyramidal neurons in layers II/III, IV, V, and VI in the current- and voltage clamp mode. A total of 234 pyramidal neurons were included in the analysis revealing distinct laminar differences. Regular spiking (RS) neurons in layer II/III have significantly lower resting membrane potential, higher threshold for action potential generation, and larger Kir and Ih amplitudes compared with layer V and VI RS neurons. These currents could improve temporal resolution in the upper layers of the AC. Additionally, the presence of a T-type Ca2+ current could be an important factor of RS neurons in these upper layers to amplify temporally closely correlated inputs. Compared with upper layers, lower layers (V and VI) exhibit a higher relative abundance of intrinsic bursting neurons. These neurons may provide layer-specific transfer functions for interlaminar, intercortical, and corticofugal information processing. 10.1093/cercor/bhn143 JF - Cereb. Cortex TI - Interlaminar Differences of Intrinsic Properties of Pyramidal Neurons in the Auditory Cortex of Mice SP - bhn143 KW - hcn KW - pyramidal AU - Huggenberger, Stefan AU - Vater, Marianne AU - Deisz, Rudolf PY - 2008/09/04/ UR - http://dx.doi.org/10.1093/cercor/bhn143 ER -