HCN channels in developing neuronal networks. Export

@article{citeulike:3484243, abstract = {Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem particularly suited for fine-tuning neuronal properties and responses because of their remarkably large and variable repertoire of functions, enabling integration of a wide range of cellular signals. Here, we discuss the involvement of HCN channels in cortical and hippocampal network maturation, and consider potential roles of developmental HCN channel dysregulation in brain disorders such as epilepsy.}, author = {Bender, Roland A A. and Baram, Tallie Z Z.}, citeulike-article-id = {3484243}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pneurobio.2008.09.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18834920}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18834920}, doi = {10.1016/j.pneurobio.2008.09.007}, issn = {0301-0082}, journal = {Progress in neurobiology}, keywords = {developpement, hcn, revue}, month = {September}, posted-at = {2008-11-06 11:53:21}, priority = {2}, title = {HCN channels in developing neuronal networks.}, url = {http://dx.doi.org/10.1016/j.pneurobio.2008.09.007}, year = {2008} }

TY - JOUR ID - citeulike:3484243 L3 - citeulike-article-id:3484243 N2 - Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem particularly suited for fine-tuning neuronal properties and responses because of their remarkably large and variable repertoire of functions, enabling integration of a wide range of cellular signals. Here, we discuss the involvement of HCN channels in cortical and hippocampal network maturation, and consider potential roles of developmental HCN channel dysregulation in brain disorders such as epilepsy. JF - Progress in neurobiology SN - 0301-0082 TI - HCN channels in developing neuronal networks. KW - developpement KW - hcn KW - revue AU - Bender, Roland A AU - Baram, Tallie Z PY - 2008/09/11/ UR - http://dx.doi.org/10.1016/j.pneurobio.2008.09.007 ER -